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Me-Tet-PEG4-COOH

  CAS No.: 2141976-30-7   Cat No.: BADC-01853 4.5  

Me-Tet-PEG4-COOH is a methyl-tetrazine functionalized ADC linker with PEG4 spacer and carboxyl group, supporting fast and selective click chemistry conjugation in antibody-drug conjugates for stable payload attachment and improved solubility. Keywords: ADC linker, methyl-tetrazine, PEG spacer, bioorthogonal chemistry, payload conjugation.

Me-Tet-PEG4-COOH

Structure of 2141976-30-7

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ADC Linker
Molecular Formula
C22H31N5O7
Molecular Weight
477.51

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
Methyltetrazine-amino-PEG4-CH2CH2COOH; Methyltetrazine-CH2NHCO-PEG4-CH2CH2COOH
IUPAC Name
3-[2-[2-[2-[3-[[4-(6-methyl-1,2,4,5-tetrazin-3-yl)phenyl]methylamino]-3-oxopropoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES
CC1=NN=C(N=N1)C2=CC=C(C=C2)CNC(=O)CCOCCOCCOCCOCCC(=O)O
InChI
InChI=1S/C22H31N5O7/c1-17-24-26-22(27-25-17)19-4-2-18(3-5-19)16-23-20(28)6-8-31-10-12-33-14-15-34-13-11-32-9-7-21(29)30/h2-5H,6-16H2,1H3,(H,23,28)(H,29,30)
InChIKey
UEWCOLSWCISPDS-UHFFFAOYSA-N

Me-Tet-PEG4-COOH, a versatile compound with diverse scientific and biomedical applications, serves as a crucial link in various fields.

Drug Delivery Systems: Utilizing Me-Tet-PEG4-COOH as a linker in drug delivery systems enhances the attachment of therapeutic agents to carrier molecules, improving drug stability and solubility for optimized pharmacokinetics.

Bioconjugation: Delving into the domain of bioconjugation, Me-Tet-PEG4-COOH acts as a vital spacer molecule, linking biomolecules like proteins, peptides, or antibodies. Its flexible and biocompatible nature ensures the proper orientation and functionality of the conjugated molecules, pivotal for the advancement of diagnostic assays and bio-sensing technologies.

Surface Modification: Me-Tet-PEG4-COOH finds utility in surface modification of nanoparticles and biomaterials, imparting hydrophilicity and preventing non-specific protein adsorption and cellular adhesion. This unique property is instrumental in creating anti-fouling surfaces, crucial for medical implants and biosensors, unlocking advancements in medical device technology.

Polymer Chemistry: In the intricate realm of polymer chemistry, Me-Tet-PEG4-COOH plays a critical role in synthesizing functionalized polymers with tailored chemical properties. Serving as a foundational building block, it enables the incorporation of carboxyl groups into polymer chains, facilitating further chemical adaptations. This versatility propels the development of customized materials for diverse industrial and biomedical applications, fueling innovation in material science.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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