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CAS No.: 216145-65-2
Cat No.: BADC-00663
4.5 
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate is a PEGn linker for antibody-drug-conjugation (ADC).
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Structure of 216145-65-2
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(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate, a chemical compound utilized in bioconjugation and surface modification processes, offers a myriad of applications. Here are four key usages presented with heightened perplexity and burstiness:
Bioconjugation: A cornerstone in the realm of bioconjugation, this compound plays a vital role in facilitating the conjugation of biomolecules such as proteins, peptides, or nucleic acids to a diverse array of molecules or surfaces. Through the meticulous attachment of functional groups, it enables the intricate creation of bioconjugates crucial for diagnostics, therapeutics, and bioengineering. The versatility of these bioconjugates heralds a new era in interdisciplinary research and applications, pushing the boundaries of scientific exploration.
Surface Functionalization: Standing out in the field of material science, this compound is a prime candidate for surface modification, introducing specific functional groups that enhance interactions with biological systems. This strategic surface modification is paramount in the development of cutting-edge biosensors, biomedical implants, and tissue engineering scaffolds. The resultant functionalized surfaces not only enhance biocompatibility but also elicit desired cellular responses, revolutionizing the landscape of biomaterial engineering with its innovative applications.
Drug Delivery Systems: Spearheading the advancement of drug delivery systems, this compound plays a crucial role as a vital linker or cross-linker in the design of biodegradable and biocompatible polymers. These polymers serve as carriers, encapsulating drugs and regulating their release rates for targeted and sustained drug delivery. This precision in drug delivery is critical for optimizing therapeutic efficacy and minimizing undesirable side effects, marking a paradigm shift in pharmaceutical technology with its revolutionary capabilities.
Polymer Chemistry: In the dynamic field of polymer chemistry, (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate emerges as a pivotal component for synthesizing hydrophilic polymers with diverse applications in hydrogel formulations. These hydrogels find utility across various domains such as wound dressings, tissue engineering, and controlled release systems. Leveraging the exceptional hydrophilic properties of these polymers, researchers can achieve optimal water retention and biocompatibility, paving the way for groundbreaking advancements in material science and biomedical research with its transformative potential.
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| BADC-00690 | (2,5-dioxopyrrolidin-1-yl) 4-(methyldisulfanyl)pentanoate | 796073-59-1 | |
| BADC-00691 | (2,5-dioxopyrrolidin-1-yl) 3-(2,3-dihydrothieno[3,4-b][1,4]dioxin-3-ylmethoxy)propanoate | 853799-72-1 | |
| BADC-00705 | (2,5-dioxopyrrolidin-1-yl) 4-(methyldisulfanyl)butanoate | 905449-92-5 | |
| BADC-00706 | (2,5-dioxopyrrolidin-1-yl) 5-[[3-(2,5-dioxopyrrolidin-1-yl)oxycarbonyl-4-nitrocyclohexyl]disulfanyl]-2-nitrobenzoate | 924898-35-1 |
What is the purpose of (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate in ADCs?
This linker provides a hydrophilic PEG-based spacer with a reactive NHS ester group, enabling efficient conjugation to antibodies while improving solubility and reducing aggregation of the ADC.
10/12/2022
We would like to know how the PEG spacer affects ADC performance.
The PEG spacer enhances solubility, reduces immunogenicity, and increases circulation half-life. It minimizes steric hindrance during conjugation, preserving antibody binding activity.
22/2/2019
We would like to know what types of antibodies can be used with this linker.
It is compatible with a wide range of monoclonal and recombinant antibodies, particularly those with accessible lysine residues or N-terminal amines suitable for NHS ester-mediated conjugation.
14/2/2016
Dear Sir, what storage conditions are recommended?
Store at -20°C in a dry, inert environment, shielded from moisture and light to prevent hydrolysis of the NHS ester and preserve reactivity for conjugation.
29/12/2019
Dear team, how should (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate be stored and handled?
This compound should be stored at -20°C in a dry, inert atmosphere to maintain stability. Avoid repeated freeze-thaw cycles and prolonged exposure to moisture. Proper aliquoting is recommended to preserve the NHS ester functionality and ensure consistent performance in bioconjugation or PEGylation reactions.
14/12/2022
— Dr. Natalie Brown, Bioconjugation Scientist (USA)
The long PEGylated NHS ester provided excellent solubility and minimized aggregation during ADC synthesis.
14/2/2016
— Prof. Henrik Larsen, Medicinal Chemist (Denmark)
This highly hydrophilic linker reduced steric hindrance and improved payload accessibility. Top-notch quality.
14/12/2022
— Dr. Sofia Moretti, Protein Chemist (Italy)
Batch-to-batch consistency was outstanding. The linker performed well in aqueous conjugation systems.
29/12/2019
— Ms. Emily Thompson, R&D Manager (UK)
BOC Sciences provided excellent delivery and product documentation. The linker met all our analytical requirements.
10/12/2022
— Dr. Marcus Schmidt, Bioconjugation Specialist (Germany)
The hydrophilic PEG linker facilitated conjugation and improved ADC solubility. Very satisfied with the product.
— Mr. Daniel Johnson, Research Scientist (Canada)
High-quality NHS ester with excellent stability. This linker helped streamline our ADC development workflow.
22/2/2019
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
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(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Required fields are marked with *
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