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(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate

  CAS No.: 216145-65-2   Cat No.: BADC-00663 4.5  

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate is a PEGn linker for antibody-drug-conjugation (ADC).

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Structure of 216145-65-2

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ADC Linker
Molecular Formula
C17H29NO10
Molecular Weight
407.41
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Room temperature, or blue ice upon request.

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Synonyms
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate; Propanoic Acid, 3-[(14-hydroxy-3, 6, 9, 12-tetraoxatetradec-1-yl)oxy]-, 2, 5-dioxo-1-pyrrolidinyl Ester
IUPAC Name
(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
Canonical SMILES
C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCO
InChI
InChI=1S/C17H29NO10/c19-4-6-24-8-10-26-12-14-27-13-11-25-9-7-23-5-3-17(22)28-18-15(20)1-2-16(18)21/h19H,1-14H2
InChIKey
XGBWDTOMQTYUMY-UHFFFAOYSA-N
Shipping
Room temperature, or blue ice upon request.

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate, a chemical compound utilized in bioconjugation and surface modification processes, offers a myriad of applications. Here are four key usages presented with heightened perplexity and burstiness:

Bioconjugation: A cornerstone in the realm of bioconjugation, this compound plays a vital role in facilitating the conjugation of biomolecules such as proteins, peptides, or nucleic acids to a diverse array of molecules or surfaces. Through the meticulous attachment of functional groups, it enables the intricate creation of bioconjugates crucial for diagnostics, therapeutics, and bioengineering. The versatility of these bioconjugates heralds a new era in interdisciplinary research and applications, pushing the boundaries of scientific exploration.

Surface Functionalization: Standing out in the field of material science, this compound is a prime candidate for surface modification, introducing specific functional groups that enhance interactions with biological systems. This strategic surface modification is paramount in the development of cutting-edge biosensors, biomedical implants, and tissue engineering scaffolds. The resultant functionalized surfaces not only enhance biocompatibility but also elicit desired cellular responses, revolutionizing the landscape of biomaterial engineering with its innovative applications.

Drug Delivery Systems: Spearheading the advancement of drug delivery systems, this compound plays a crucial role as a vital linker or cross-linker in the design of biodegradable and biocompatible polymers. These polymers serve as carriers, encapsulating drugs and regulating their release rates for targeted and sustained drug delivery. This precision in drug delivery is critical for optimizing therapeutic efficacy and minimizing undesirable side effects, marking a paradigm shift in pharmaceutical technology with its revolutionary capabilities.

Polymer Chemistry: In the dynamic field of polymer chemistry, (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate emerges as a pivotal component for synthesizing hydrophilic polymers with diverse applications in hydrogel formulations. These hydrogels find utility across various domains such as wound dressings, tissue engineering, and controlled release systems. Leveraging the exceptional hydrophilic properties of these polymers, researchers can achieve optimal water retention and biocompatibility, paving the way for groundbreaking advancements in material science and biomedical research with its transformative potential.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: (2,5-dioxopyrrolidin-1-yl) 5-[[3-(2,5-dioxopyrrolidin-1-yl)oxycarbonyl-4-nitrocyclohexyl]disulfanyl]-2-nitrobenzoate | 2,5-dioxopyrrolidin-1-yl 4-((5-(dimethylcarbamoyl)pyridin-2-yl)disulfanyl)butanoate | Amino-SS-PEG12-acid | γ-Amanitin | MCC-DM1 | Colchicine | 3-Azido-N-Boc-D-Alanine | DC-1 | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate
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