Name: Fmoc-Val-Ala-OH
Brand: BOC Sciences
Price: 298 USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

500 mg

$298

In stock

Synonyms

(S)-2-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamido)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-L-alanine

IUPAC Name

(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoyl]amino]propanoic acid

Canonical SMILES

CC(C)C(C(=O)NC(C)C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13

InChI

InChI=1S/C23H26N2O5/c1-13(2)20(21(26)24-14(3)22(27)28)25-23(29)30-12-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,13-14,19-20H,12H2,1-3H3,(H,24,26)(H,25,29)(H,27,28)/t14-,20-/m0/s1

InChIKey

KQZMZNLKVKGMJS-XOBRGWDASA-N

Density

1.2±0.1 g/cm3

Solubility

Soluble in DMF (Slightly), DMSO (Slightly)

Appearance

White to Off-White Solid

Boiling Point

676.7±45.0 °C at 760 mmHg

Fmoc-Val-Ala-OH, also known as N-[(9-Fluorenylmethoxycarbonyl)-L-valyl]-L-alanine, is a protected dipeptide utilized in peptide synthesis and biochemical research. Here are four key applications of this compound:

Peptide Synthesis: Serving as a cornerstone in solid-phase peptide synthesis (SPPS), Fmoc-Val-Ala-OH plays a pivotal role in crafting precise peptide sequences. Its Fmoc protective group enables methodical deprotection steps, ensuring the meticulous assembly of peptides. This dipeptide is essential for constructing intricate peptides utilized in pharmaceutical research and diagnostics, contributing to advancements in therapeutic development.

Protein Engineering: In the realm of protein engineering, researchers leverage Fmoc-Val-Ala-OH to introduce specific amino acid sequences into target proteins. By incorporating this dipeptide, scientists can manipulate the structure and functionality of proteins, facilitating the study of their properties or the design of novel proteins with unique characteristics.

Biophysical Studies: Delving into biophysical studies, Fmoc-Val-Ala-OH serves as a tool for investigating peptide folding, stability, and interactions. By synthesizing peptides containing this dipeptide, researchers can explore their conformational dynamics under diverse conditions. This in-depth understanding is crucial for unravelling the complexities of protein folding disorders and formulating effective therapeutic strategies.

Drug Discovery: Through the creation of peptide libraries using combinatorial chemistry, researchers can screen for peptides exhibiting high affinity and specificity towards target molecules. These peptide drugs hold the potential to function as inhibitors, activators, or signaling molecules in therapeutic contexts, offering promising avenues for innovative drug interventions.