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ADC Manufacture
BOC Sciences provides custom GMP-grade antibody-drug conjugates (ADC) manufacturing service to meet clinical and commercial development needs.
We have GMP and ISO-certified contract manufacturing facilities. Our strong expertise in process development, characterization, optimization, and scale-up can support successful GMP manufacturing and productive long-term cooperative relationships with pharmaceutical companies, institutions, and universities.
BOC Sciences offers a full and flexible range of ADC manufacturing services, from process development & analytical support to GMP production. Our services include biopharmaceutical contract research and development, process development, cGMP manufacturing, QA and QC solutions for scientific research program, preclinical, clinical, and commercial supply.
Our ADC manufacturing solutions
- GMP chemical manufacturing
- ADC coupling, purification, and filling
Based on our extensive experience with organic synthetic chemistry and R&D in GMP environments, BOC Sciences can provide GMP-scale route design and optimization for payloads, cytotoxins, and payload connectors, including the use of HPAPI products.
After the verification of the small-scale coupling scheme, ADC coupling can be achieved in a GMP-certified reactor. We use advanced filtration equipment (such as ultrafiltration and tangential flow filtration (TFF) systems) to remove therapeutic impurities. ADC products are purified using a disposable chromatography system and filled into sterile vials through a GMP aseptic filling pipeline.
Key aspects of our ADC manufacturing include
- cGMP laboratory
- Advanced ADC synthesis covering multiple chemical techniques
- Dedicated facilities and personnel for isolator processing, clean room manufacturing
- Development and manufacturing of gram and kilogram scales
- Regulatory support services
Cooperation with BOC Sciences
BOC Sciences' services are designed to ensure that the goals of each project are met or exceeded. We are known to our customers as a professional and attentive partner who delivers quality results.
Our advantages
- Exclusive technology
- Excellent R&D team
- Optimizes R&D process
- High-quality, low-cost products
- Personalized services
- Strict quality control
* Only for research. Not suitable for any diagnostic or therapeutic use.
