Name: Fmoc-Val-Ala-PAB-OH
Brand: BOC Sciences
Price: 298 USD
Availability: MadeToOrder

Synonyms

Fmoc-Val-Ala-PAB; (9H-Fluoren-9-yl)methyl ((S)-1-(((S)-1-((4-(hydroxymethyl)phenyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)carbamate

IUPAC Name

9H-fluoren-9-ylmethyl N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate

Canonical SMILES

CC(C)C(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)CO)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

InChI

InChI=1S/C30H33N3O5/c1-18(2)27(29(36)31-19(3)28(35)32-21-14-12-20(16-34)13-15-21)33-30(37)38-17-26-24-10-6-4-8-22(24)23-9-5-7-11-25(23)26/h4-15,18-19,26-27,34H,16-17H2,1-3H3,(H,31,36)(H,32,35)(H,33,37)/t19-,27-/m0/s1

InChIKey

PIEQFKSWCKVBTP-PPHZAIPVSA-N

Density

1.3±0.1 g/cm3

Solubility

10 mm in DMSO

Melting Point

218 °C(dec.)

Flash Point

444.4±34.3 °C

Index Of Refraction

1.620

Vapor Pressure

0.0±3.0 mmHg at 25°C

Appearance

White to light yellow powder to crystal

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature

Storage

Store at -20 °C, keep in dry and avoid sunlight.

Boiling Point

811.1±65.0 °C at 760 mmHg

Form

Solid

Fmoc-Val-Ala-PAB-OH, a synthetic peptide prominent in biochemical and pharmaceutical research, finds diverse applications across various fields.

Peptide Synthesis: Acting as a fundamental building block in peptide synthesis, Fmoc-Val-Ala-PAB-OH facilitates the construction of intricate peptide chains through solid-phase techniques. The inclusion of its Fmoc (9-fluorenylmethyloxycarbonyl) group enables sequential peptide assembly, ensuring the production of highly pure peptides essential for a myriad of research and therapeutic endeavors.

Drug Development: In the realm of pharmaceutical innovation, Fmoc-Val-Ala-PAB-OH plays a pivotal role in the design and synthesis of peptide-based drug candidates. These peptides, capable of mimicking natural biological molecules, target specific physiological pathways, with researchers customizing peptide sequences and structures to enhance therapeutic efficacy and safety profiles.

Protease Substrate: Serving as a vital substrate for investigating protease activity, Fmoc-Val-Ala-PAB-OH allows researchers to delve into the specificity and kinetic properties of proteases, pivotal players in a myriad of biological processes. Through such studies, researchers unearth potential protease inhibitors or activators crucial in combatting diseases like cancer and inflammatory disorders, a testament to the peptide’s versatility in biomedical research.