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MC-Ala-Ala-PAB

  CAS No.: 1949793-44-5   Cat No.: BADC-01703 4.5  

MC-Ala-Ala-PAB is a cleavable peptide ADC linker with alanine-alanine dipeptide sequence and para-aminobenzyl spacer, supporting controlled drug release and improved conjugation stability in antibody-drug conjugates. Keywords: ADC linker, cleavable linker, peptide linker, controlled release, ADC stability.

MC-Ala-Ala-PAB

Structure of 1949793-44-5

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ADC Linker
Molecular Formula
C23H30N4O6
Molecular Weight
458.51

* For research and manufacturing use only. We do not sell to patients.

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IUPAC Name
6-(2,5-dioxopyrrol-1-yl)-N-[(2S)-1-[[(2S)-1-[4-(hydroxymethyl)anilino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]hexanamide
Canonical SMILES
CC(C(=O)NC(C)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCCCCN2C(=O)C=CC2=O
InChI
InChI=1S/C23H30N4O6/c1-15(24-19(29)6-4-3-5-13-27-20(30)11-12-21(27)31)22(32)25-16(2)23(33)26-18-9-7-17(14-28)8-10-18/h7-12,15-16,28H,3-6,13-14H2,1-2H3,(H,24,29)(H,25,32)(H,26,33)/t15-,16-/m0/s1
InChIKey
PKHVWJOCRXHNME-HOTGVXAUSA-N

MC-Ala-Ala-PAB, a versatile peptide-based compound, holds great promise in scientific research and potential therapeutics.

Drug Delivery Systems: Incorporating MC-Ala-Ala-PAB into drug delivery systems revolutionizes the targeted release of therapeutic agents. Serving as a peptide linker or protective group, it orchestrates controlled drug delivery at specific sites, diminishing side effects and amplifying efficacy. This technology, especially crucial in cancer treatments, ensures precise drug deployment, safeguarding healthy tissues from detrimental repercussions.

Protease Activity Assays: Serving as a substrate for protease enzymes, MC-Ala-Ala-PAB emerges as a pivotal asset in enzymatic activity assays. Researchers leverage this compound to gauge the activity of distinct proteases through cleavage monitoring, measurable via spectroscopic techniques. This application plays a pivotal role in screening protease inhibitors, vital for advancements in pharmaceutical interventions against conditions such as hypertension and viral infections.

Bioconjugation Techniques: Harnessing MC-Ala-Ala-PAB in bioconjugation methodologies enables the attachment of diverse molecules like proteins or fluorophores to peptides or other biomolecules. Its unique structure facilitates the creation of enduring conjugates, allowing precise labeling or modification of molecules for imaging or therapeutic pursuits. These techniques propel research in diagnostics and personalized medicine to new frontiers.

Anticancer Research: In the realm of oncology, MC-Ala-Ala-PAB is the subject of intense scrutiny for its potential in formulating novel anticancer agents. Its role as a prodrug component renders it ideal for crafting molecules that activate exclusively within the tumor microenvironment, minimizing systemic toxicity.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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