Name: Fmoc-GGFG-OH
Brand: BOC Sciences
Price: 228 USD
Availability: MadeToOrder

Synonyms

Fmoc-Gly-Gly-Phe-Gly-OH; (((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycyl-L-phenylalanylglycine

IUPAC Name

2-[[(2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetic acid

Canonical SMILES

C1=CC=C(C=C1)CC(C(=O)NCC(=O)O)NC(=O)CNC(=O)CNC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24

InChI

InChI=1S/C30H30N4O7/c35-26(31-16-27(36)34-25(29(39)32-17-28(37)38)14-19-8-2-1-3-9-19)15-33-30(40)41-18-24-22-12-6-4-10-20(22)21-11-5-7-13-23(21)24/h1-13,24-25H,14-18H2,(H,31,35)(H,32,39)(H,33,40)(H,34,36)(H,37,38)/t25-/m0/s1

InChIKey

LCOCGQVZUSLQJD-VWLOTQADSA-N

Appearance

White Solid

Fmoc-GGFG-OH, a fluorine-modified peptide with diverse bioscience applications, is a key player in research and therapeutic advancements. Here are four essential applications of Fmoc-GGFG-OH:

Peptide Synthesis: In the realm of solid-phase peptide synthesis, Fmoc-GGFG-OH shines as a foundational element for constructing complex peptides and proteins. The Fmoc group acts as a safeguard, ensuring the precise assembly of sequences during synthesis. This application is indispensable for crafting tailored peptides for both research purposes and therapeutic applications.

Drug Delivery Systems: Delving into the realm of targeted drug delivery, researchers are exploring the potential of modified peptides like Fmoc-GGFG-OH. By tethering therapeutic compounds to this peptide, novel conjugates are fashioned to transport drugs directly to specific cells or tissues. This strategic approach enhances the efficacy and precision of treatments, particularly in the context of cancer therapy, offering new avenues for more effective and targeted drug administration.

Bioconjugation Studies: Fmoc-GGFG-OH takes center stage in bioconjugation endeavors, serving as a bridge to connect peptides with a myriad of molecules, such as fluorescent dyes or pharmaceuticals. The glycine-glycine-phenylalanine-glycine (GGFG) sequence within this peptide offers both flexibility and stability in the linker region, enabling seamless molecular interactions. This methodology streamlines the detection and monitoring of biological processes, both in controlled laboratory settings and within living organisms.

Protein Engineering: Pioneering protein engineering scientists leverage the unique properties of Fmoc-GGFG-OH to refine and enhance protein functionalities. By integrating this peptide into protein structures, researchers can explore its impact on crucial aspects like folding, stability, and enzymatic activity. This application is pivotal in the quest to develop novel biopharmaceuticals and unravel the intricate mechanisms governing protein behavior.