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Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00972 | 500 mg | $298 | Inquiry |
Fmoc-Gly-Gly-Phe-OH is a synthetic tripeptide commonly used in peptide synthesis and biochemical research. Here are some key applications of Fmoc-Gly-Gly-Phe-OH:
Peptide Synthesis: Fmoc-Gly-Gly-Phe-OH is a building block in the solid-phase peptide synthesis (SPPS) process. Its Fmoc (9-fluorenylmethyloxycarbonyl) group provides a temporary protective function, allowing for sequential coupling and de-protection cycles. This helps in constructing longer peptide chains with precise amino acid sequences.
Drug Development: Researchers use Fmoc-Gly-Gly-Phe-OH to design and synthesize peptide-based drug candidates. The inclusion of this tripeptide can help enhance the bioavailability and stability of therapeutic peptides. It plays a role in producing peptides which may act as inhibitors or mimetics of natural ligands in various disease models.
Biochemical Assays: Fmoc-Gly-Gly-Phe-OH is often employed in the development of substrates for enzymatic activity assays. By incorporating the tripeptide into substrates for proteases, researchers can study enzyme kinetics and inhibitor efficacy. This is integral in screening potential drug candidates and understanding enzyme specificity.
Protein-Protein Interaction Studies: In molecular biology, Fmoc-Gly-Gly-Phe-OH can be used to investigate protein-protein interactions. It can be incorporated into peptides that mimic protein binding sites, helping in the study of binding affinities and interaction mechanisms. This insight is important for drug discovery and understanding cellular signaling pathways.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
