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Fmoc-Gly-Gly-Phe-OtBu is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01104 | -- | $-- | Inquiry |
Fmoc-Gly-Gly-Phe-OtBu is a peptide compound commonly used in the field of peptide synthesis. It serves as an important building block in the solid-phase peptide synthesis (SPPS) method, where it is utilized to form longer peptide chains. The Fmoc (9-fluorenylmethyloxycarbonyl) group is particularly useful as a temporary protecting group for the amino terminus of the peptide during synthesis. The Fmoc group is easily removed under mildly basic conditions, which allows for sequential addition of amino acids while minimizing side reactions. This functionality makes Fmoc-Gly-Gly-Phe-OtBu a versatile intermediate for complex peptide assembly.
Additionally, Fmoc-Gly-Gly-Phe-OtBu is employed in the development of bioactive peptides for therapeutic applications. The presence of phenylalanine (Phe) in the sequence provides aromaticity, which is essential for certain receptor interactions or to impart specific structural properties to the resulting peptides. This can be crucial in the development of peptides that target proteins or receptors involved in disease mechanisms. Moreover, the glycine residues (Gly-Gly) may contribute to flexibility in the peptide structure, facilitating its interaction with other biomolecules.
The OtBu (tert-butoxy) group, which protects the carboxyl group during synthesis, is another significant feature of Fmoc-Gly-Gly-Phe-OtBu. This protective group helps maintain stability during the synthesis process and can be removed selectively when needed. The OtBu group also contributes to the compound's overall stability, preventing premature cleavage or reactions that could compromise the integrity of the peptide chain. This makes Fmoc-Gly-Gly-Phe-OtBu an ideal candidate for use in controlled synthesis protocols, where maintaining precise structural integrity is essential.
In addition to its application in peptide synthesis, Fmoc-Gly-Gly-Phe-OtBu is valuable in studies of protein folding and interaction. The specific arrangement of amino acids within this compound can be tailored to mimic certain structural motifs found in proteins, making it a useful tool in structural biology. By incorporating such compounds into experimental models, researchers can gain insights into the principles of peptide folding, stability, and the mechanisms by which peptides interact with their biological targets.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
