Name: m-PEG4-COOH
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

m-PEG3-CH2CH2COOH; 2,5,8,11-Tetraoxatetradecan-14-oic acid; m-PEG4-Acid; 4,7,10,13-Tetraoxatetradecanoic acid; 2,5,8,11-Tetraoxa-14-tetradecanoic Acid; mPEG3-propionic acid; COOHCH2CH2-PEG3-OME

IUPAC Name

3-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]propanoic acid

Canonical SMILES

COCCOCCOCCOCCC(=O)O

InChI

InChI=1S/C10H20O6/c1-13-4-5-15-8-9-16-7-6-14-3-2-10(11)12/h2-9H2,1H3,(H,11,12)

InChIKey

ZMCJTXKSDDFJRG-UHFFFAOYSA-N

Density

1.105±0.06 g/cm3 (Predicted)

Solubility

Soluble in Water

Flash Point

129.8±18.6 °C

Index Of Refraction

1.445

Vapor Pressure

0.0±1.7 mmHg at 25°C

Appearance

Pale Yellow or Colorless Oily Matter

Shipping

Room temperature, or blue ice upon request.

Storage

Store at 2-8°C

Boiling Point

352.3±32.0 °C at 760 mmHg

Form

Solid

m-PEG4-COOH, or methoxy polyethylene glycol with a carboxyl functional group, is a versatile compound used in a variety of bioscience applications. Here are some key applications of m-PEG4-COOH:

Drug Delivery: m-PEG4-COOH is commonly used in drug delivery systems to enhance the solubility and stability of pharmaceuticals. By attaching m-PEG4-COOH to drug molecules, researchers can improve their bioavailability and extend circulation time in the bloodstream. This conjugation helps in creating more effective treatments with reduced side effects.

Bioconjugation: The carboxyl functional group in m-PEG4-COOH facilitates the conjugation of biomolecules such as proteins, peptides, and antibodies. This allows for the creation of pegylated compounds that exhibit improved in vivo stability and reduced immunogenicity. Such modifications are critical for the development of biologics with enhanced therapeutic properties.

Surface Modification: m-PEG4-COOH is used in surface modification techniques to improve the biocompatibility of materials used in medical devices and implants. By coating surfaces with m-PEG4-COOH, it is possible to reduce protein adsorption and cell adhesion, minimizing foreign body responses. This makes it an essential compound in the development of more durable and safe medical implants.

Diagnostic Assays: In diagnostic assays, m-PEG4-COOH can be employed as a linker or spacer molecule to attach labels or probes to the target analyte. This enables the development of sensitive and specific assays for biomarker detection in clinical samples. The use of m-PEG4-COOH enhances assay performance and reliability, facilitating accurate diagnostics in medical research and practice.