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m-PEG4-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01145 | -- | $-- | Inquiry |
m-PEG4-COOH, or methoxy polyethylene glycol with a carboxyl functional group, is a versatile compound used in a variety of bioscience applications. Here are some key applications of m-PEG4-COOH:
Drug Delivery: m-PEG4-COOH is commonly used in drug delivery systems to enhance the solubility and stability of pharmaceuticals. By attaching m-PEG4-COOH to drug molecules, researchers can improve their bioavailability and extend circulation time in the bloodstream. This conjugation helps in creating more effective treatments with reduced side effects.
Bioconjugation: The carboxyl functional group in m-PEG4-COOH facilitates the conjugation of biomolecules such as proteins, peptides, and antibodies. This allows for the creation of pegylated compounds that exhibit improved in vivo stability and reduced immunogenicity. Such modifications are critical for the development of biologics with enhanced therapeutic properties.
Surface Modification: m-PEG4-COOH is used in surface modification techniques to improve the biocompatibility of materials used in medical devices and implants. By coating surfaces with m-PEG4-COOH, it is possible to reduce protein adsorption and cell adhesion, minimizing foreign body responses. This makes it an essential compound in the development of more durable and safe medical implants.
Diagnostic Assays: In diagnostic assays, m-PEG4-COOH can be employed as a linker or spacer molecule to attach labels or probes to the target analyte. This enables the development of sensitive and specific assays for biomarker detection in clinical samples. The use of m-PEG4-COOH enhances assay performance and reliability, facilitating accurate diagnostics in medical research and practice.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
