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m-PEG8-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00889 | -- | $-- | Inquiry |
m-PEG8-COOH, a derivative of polyethylene glycol showcasing a carboxylic acid functional group, finds extensive utility across varied scientific and industrial domains. Here are four key applications of m-PEG8-COOH:
Drug Delivery: The versatile m-PEG8-COOH molecule assumes a pivotal role in enhancing drug delivery systems by boosting the solubility and stability of therapeutic compounds. Through conjugation of drugs to this molecular entity, pharmaceutical formulations achieve prolonged circulation in the bloodstream, thereby amplifying the bioavailability and efficacy of treatments.
Bioconjugation: Within the bioconjugation methodologies, m-PEG8-COOH emerges as a critical linker for binding biomolecules such as proteins or peptides to serve a myriad of biotechnological and therapeutic objectives. The reactive carboxylic group acts as a catalyst for coupling reactions, facilitating the creation of robust conjugates that enhance protein stability and mitigate immunogenic responses in clinical contexts. This utilization underscores the significance of m-PEG8-COOH in propelling advancements in bioconjugation technologies.
Surface Modification: Unleashing the potential of m-PEG8-COOH, surfaces including nanoparticles can undergo intelligent modifications to boost biocompatibility and deter nonspecific interactions. Coating surfaces with this molecular entity enables researchers to restrict protein adsorption and prevent unwanted cell adhesion, particularly advantageous in the development of cutting-edge biomedical devices and diagnostic assays. This application highlights the pivotal role played by m-PEG8-COOH in refining surface modification strategies.
Polymer Chemistry: m-PEG8-COOH emerges as a fundamental building block for crafting amphiphilic polymers tailored to a plethora of applications. These polymers have the capability to self-assemble into micelles or hydrogels, making them ideal candidates for drug delivery systems and tissue engineering endeavors. The integration of m-PEG8-COOH allows for meticulous adjustments of polymer properties, encompassing hydrophilicity and mechanical strength, underscoring its significance in fueling innovations within polymer chemistry.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
