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Propargyl-PEG2-acid

CAS No.: 1859379-85-3

Cat No.: BADC-01014

Purity: ≥98.0% 4.5

Propargyl-PEG2-acid is an alkyne-functionalized PEG linker with a carboxylic acid group, supporting copper-free click chemistry in ADC construction. Its PEG2 spacer offers hydrophilicity and facilitates site-specific payload conjugation for enhanced therapeutic efficacy.

Propargyl-PEG2-acid

Structure of 1859379-85-3

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Category

ADC Linker

Molecular Formula

C8H12O4

Molecular Weight

172.18

Shipping

Room temperature, or blue ice upon request.

Shipping

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

* For research and manufacturing use only. We do not sell to patients.

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Delivery of 200+ ADCs annually;
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CDMO and CMO support.

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Synonyms

Propyne-PEG1-CH2CH2COOH; 3-(2-(Prop-2-yn-1-yloxy)ethoxy)propanoic acid; 3-[2-(2-Propyn-1-yloxy)ethoxy]propanoic acid; Propargyl-PEG1-COOH; Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-

IUPAC Name

3-(2-prop-2-ynoxyethoxy)propanoic acid

Canonical SMILES

C#CCOCCOCCC(=O)O

InChI

InChI=1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)

InChIKey

NNWHATPXNWOQKD-UHFFFAOYSA-N

Density

1.1±0.1 g/cm3

Solubility

Soluble in DMSO

Appearance

Pale Yellow Oily Matter

Shelf Life

0-4°C for short term (days to weeks), or -20°C for long term (months).

Shipping

Room temperature, or blue ice upon request.

Storage

Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)

Pictograms

Corrosive; Irritant

Signal Word

Danger

Boiling Point

306.6±27.0°C at 760 mmHg

Form

Solid

Biological Activity

Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]

Catalog	Product Name	CAS	Inquiry
BADC-00906	Propargyl-PEG5-acid	1245823-51-1
BADC-00928	Propargyl-PEG3-acid	1347760-82-0
BADC-01026	Propargyl-PEG6-acid	1951438-84-8
BADC-01035	Propargyl-PEG8-acid	2055014-94-1
BADC-01956	Propargyl-PEG7-acid	2093154-00-6

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