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Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz

  CAS No.:   Cat No.: BADC-01880 4.5  

Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz is a complex peptide-based ADC linker intermediate offering enzyme-sensitive cleavable properties for controlled payload release in antibody-drug conjugates. Keywords: ADC linker, peptide linker, enzyme-cleavable, controlled release, bioconjugation.

Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz

Structure of

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ADC Linker
Molecular Formula
C45H49N7O12
Molecular Weight
879.91

* For research and manufacturing use only. We do not sell to patients.

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IUPAC Name
benzyl 2-[[[2-[[2-[[[2-[[(2S)-2-[[2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetyl]amino]acetyl]amino]methoxy]acetate
Canonical SMILES
C1=CC=C(C=C1)CC(C(=O)NCC(=O)NCOCC(=O)NCC(=O)NCOCC(=O)OCC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)OCC3C4=CC=CC=C4C5=CC=CC=C35
InChI
InChI=1S/C45H49N7O12/c53-38(22-49-45(60)64-25-36-34-17-9-7-15-32(34)33-16-8-10-18-35(33)36)46-23-41(56)52-37(19-30-11-3-1-4-12-30)44(59)48-21-40(55)50-28-61-26-42(57)47-20-39(54)51-29-62-27-43(58)63-24-31-13-5-2-6-14-31/h1-18,36-37H,19-29H2,(H,46,53)(H,47,57)(H,48,59)(H,49,60)(H,50,55)(H,51,54)(H,52,56)/t37-/m0/s1
InChIKey
SKZQGPROKJGTIS-QNGWXLTQSA-N

Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz is a synthetic peptide commonly used in peptide synthesis and molecular biology. Here are some key applications:

Peptide Synthesis: Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz serves as a building block in the synthesis of larger peptides and proteins. Its unique structure allows for precise incorporation into peptide chains. This makes it widely applicable in the development of new peptides for pharmaceutical and research applications.

Structural Biology: This synthetic peptide can be used in structural biology to study protein folding and interactions. By incorporating it into model peptides, researchers can use techniques like NMR and X-ray crystallography to analyze structural dynamics. Understanding these interactions is crucial for drug design and protein engineering.

Drug Delivery Systems: Fmoc-Gly-Gly-Phe-Gly-CH2-O-CH2-Gly-CH2-O-CH2-Cbz can be incorporated into drug delivery systems to target specific tissues or cells. This peptide can be designed to enhance the stability and bioavailability of therapeutic molecules. It is particularly beneficial in the development of targeted therapies with minimal side effects.

Bioconjugation: This peptide can be used for bioconjugation, linking biomolecules such as antibodies, enzymes, or nucleic acids to various surfaces or carriers. The versatility of its functional groups makes it suitable for creating complex bioconjugates with enhanced functionality. These bioconjugates are valuable in diagnostics, imaging, and therapeutic applications.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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