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BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01165 | -- | $-- | Inquiry |
BS3 Crosslinker, a bis(sulfosuccinimidyl) suberate crosslinking reagent, is utilized widely in biochemical research for its non-cleavable and homobifunctional properties. Here are four key applications of BS3 Crosslinker:
Protein-Protein Interaction Studies: In the realm of understanding protein interactions, BS3 Crosslinker plays a pivotal role. By covalently linking interacting proteins together, researchers can stabilize transient complexes, enabling detailed analysis. This innovative technique allows for the detection of interaction partners within intricate biological mixtures, shedding light on complex protein networks.
Structural Biology: Delving into the architecture of proteins within complexes, BS3 Crosslinker is a valuable tool in structural biology. Preceding structural characterization techniques like mass spectrometry or cryo-EM, crosslinking proteins with BS3 provides essential distance constraints for precise 3D modeling. This detailed spatial information enhances our grasp of protein structure and function, offering insights into molecular mechanisms.
Cell Surface Receptor Mapping: With its unique water solubility, BS3 Crosslinker aids in mapping cell surface receptors and their interactions. Capable of permeating the cell membrane without infiltrating intracellular components, this reagent facilitates the crosslinking of surface proteins for in-depth study. By dissecting receptor complexes and signaling pathways crucial for cellular communication, BS3 Crosslinker contributes to unraveling the intricacies of cell signaling.
Antibody-Antigen Complex Analysis: In the realm of immunological studies, BS3 Crosslinker emerges as a critical tool for stabilizing antibody-antigen complexes. By crosslinking these complexes, researchers can analyze binding affinities, map epitopes, and investigate receptor-ligand interactions. This in-depth analysis is instrumental in the development of diagnostic tools and therapeutic antibodies, advancing the field of immunotherapy and precision medicine.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
