BS3 Crosslinker - CAS 82436-77-9

BS3 Crosslinker - CAS 82436-77-9 Catalog number: BADC-01165

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
BS3 Crosslinker
CAS
82436-77-9
Catalog Number
BADC-01165
Molecular Formula
C16H20N2O14S2
Molecular Weight
528.47
BS3 Crosslinker

Ordering Information

Catalog Number Size Price Quantity
BADC-01165 -- $--
Inquiry
Description
BS3 Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
Bis(sulfosuccinimidyl)suberate
IUPAC Name
1-[8-(2,5-dioxo-3-sulfopyrrolidin-1-yl)oxy-8-oxooctanoyl]oxy-2,5-dioxopyrrolidine-3-sulfonic acid
Canonical SMILES
C1C(C(=O)N(C1=O)OC(=O)CCCCCCC(=O)ON2C(=O)CC(C2=O)S(=O)(=O)O)S(=O)(=O)O
InChI
InChI=1S/C16H20N2O14S2/c19-11-7-9(33(25,26)27)15(23)17(11)31-13(21)5-3-1-2-4-6-14(22)32-18-12(20)8-10(16(18)24)34(28,29)30/h9-10H,1-8H2,(H,25,26,27)(H,28,29,30)
InChIKey
VYLDEYYOISNGST-UHFFFAOYSA-N
Solubility
10 mm in DMSO
Melting Point
>300°C
LogP
-0.03120
PSA
255.69000
In Vitro
Treatment of intact cells with the homobifunctional crosslinker BS3 Crosslinker produces similar amounts of covalent dimer in both normal and SAO cells. In SAO cells, copies of normal band 3 can be distinguished from SAO band 3 by treating with H2DIDS to form a crosslink between major chymotryptic fragments (60 kDa and 35 kDa) within one subunit. Successive treatment of cells with [3H]-4,4'-diisothiocyanatodihydrostilbene-2,2'-disulfonate ([3H]H2DIDS), BS3, and chymotrypsin gives 3H-labeled products that include homodimer of normal band 3 as well as products of crosslinking normal band 3 with the 60- and 35-kDa fragment of SAO band 3.
Appearance
Light tan powder
Purity
≥ 97.0 %
Shipping
Room temperature
Storage
Store at -5 ℃, keep in dry and avoid sunlight.
Pictograms
Irritant
Signal Word
Warning
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Why Choose BOC Sciences?

Customer Support

Providing excellent 24/7 customer service and support

Project Management

Offering 100% high-quality services at all stages

Quality Assurance

Ensuring the quality and reliability of products or services

Global Delivery

Ensuring timely delivery of products worldwide

Questions & Comments
Verification code
Send Inquiry
Verification code
Inquiry Basket