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CAS No.: 317331-86-5
Cat No.: BADC-00464
Purity: ≥98%
4.5 
N-succinimidyl-5-(2-pyridyldithio)valerate is a disulfide-containing crosslinker or linker building block for redox-responsive bioconjugation and ADC-related linker design. The disulfide bond provides a reduction-sensitive element, while the terminal reactive groups enable attachment to appropriately functionalized biomolecules or small-molecule partners. The molecule uses nhs/succinimidyl ester (amine-reactive) for antibody lysines/primary amines (common orientation) on one side and pyridyl-disulfide / activated disulfide handle for thiol-containing payloads or thiol exchange partners on the other, with disulfide trigger with c5/alkyl spacer segment providing the spacer/cleavable region. Conjugation orientation and reduction sensitivity should be evaluated in the context of the final construct because local substitution and neighboring groups can influence disulfide behavior.
Structure of 317331-86-5
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N-succinimidyl-5-(2-pyridyldithio)valerate
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N-succinimidyl-5-(2-pyridyldithio)valerate
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