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MC-VC-PAB-Azide is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01283 | -- | $-- | Inquiry |
MC-VC-PAB-Azide is a versatile chemical linker used in various applications within the fields of medicinal chemistry and biotechnology. Here are some key applications of MC-VC-PAB-Azide:
Antibody-Drug Conjugates (ADCs): MC-VC-PAB-Azide is commonly used as a linker in the development of antibody-drug conjugates. This linker connects the cytotoxic drug to the antibody, ensuring precise delivery to tumor cells while minimizing damage to healthy tissues. The azide group allows for a click chemistry reaction, facilitating stable and efficient drug conjugation.
Bioconjugation: In bioconjugation studies, MC-VC-PAB-Azide helps bond biomolecules such as proteins and peptides to various chemical entities. The azide function permits efficient and selective attachment through click chemistry, maintaining biomolecule integrity. This application is pivotal in creating modified biomolecules for drug delivery systems and diagnostics.
Proteomics: In proteomic applications, MC-VC-PAB-Azide is used to tag and identify proteins within complex biological samples. It enables the enrichment and identification of specific proteins through click chemistry reactions with labeled alkyne molecules. This assists researchers in understanding protein interactions and functions in various cellular contexts.
Targeted Drug Delivery: MC-VC-PAB-Azide is instrumental in designing drug delivery systems that target specific cells or tissues. The azide group can be utilized to attach targeting ligands that seek out particular cell types, ensuring localized drug delivery. This enhances therapeutic efficacy and reduces systemic side effects, optimizing treatment outcomes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
