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MC-VC-PAB-NH2

  CAS No.: 1616727-20-8   Cat No.: BADC-00976   Purity: >98.0% 4.5  

MC-VC-PAB-NH2 is a maleimide-activated cleavable ADC linker with Val-Cit dipeptide and PAB spacer, featuring terminal amine for efficient antibody conjugation and selective drug release.

MC-VC-PAB-NH2

Structure of 1616727-20-8

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Category
ADC Linker
Molecular Formula
C31H46N8O8
Molecular Weight
658.75
Shipping
-20°C (International: -20°C)
Shipping
-20°C

* For research and manufacturing use only. We do not sell to patients.

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Capabilities & Facilities

Popular Publications Citing BOC Sciences Products
Synonyms
[4-[[(2S)-5-(carbamoylamino)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]pentanoyl]amino]phenyl]methyl N-(2-aminoethyl)carbamate
IUPAC Name
Canonical SMILES
CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)COC(=O)NCCN)NC(=O)CCCCCN2C(=O)C=CC2=O
InChI
InChI=1S/C31H46N8O8/c1-20(2)27(38-24(40)8-4-3-5-18-39-25(41)13-14-26(39)42)29(44)37-23(7-6-16-34-30(33)45)28(43)36-22-11-9-21(10-12-22)19-47-31(46)35-17-15-32/h9-14,20,23,27H,3-8,15-19,32H2,1-2H3,(H,35,46)(H,36,43)(H,37,44)(H,38,40)(H3,33,34,45)/t23-,27-/m0/s1
InChIKey
CNKMVFCYQSFWSZ-HOFKKMOUSA-N
Solubility
10 mm in DMSO
Appearance
Solid
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
-20°C (International: -20°C)
Storage
-20°C
Form
Solid

MC-VC-PAB-NH2, a chemical linker utilized in drug design, plays a pivotal role in the development of antibody-drug conjugates (ADCs).

Antibody-Drug Conjugates (ADCs) Development: MC-VC-PAB-NH2 serves as the crucial bridge linking cytotoxic drugs to antibodies, enabling targeted delivery to cancer cells while sparing healthy tissues. By facilitating precise drug targeting, this linker enhances the therapeutic index and reduces side effects significantly. Its stability and cleavage properties ensure drug release upon internalization by target cells, thereby amplifying the efficacy of cancer treatments.

Bioconjugation Studies: In the realm of bioconjugation techniques, MC-VC-PAB-NH2 plays a pivotal role in exploring protein interactions and modifications. By enabling the attachment of diverse biomolecules to proteins of interest, scientists can delve deep into protein function and structure. The utilization of linkers like MC-VC-PAB-NH2 is indispensable for biosensor and diagnostic tool development, opening new avenues in bioanalytical research.

Pharmaceutical Research: At the forefront of pharmaceutical innovation, MC-VC-PAB-NH2 is a cornerstone in the development of novel therapeutic agents. Researchers leverage its unique properties to study its behavior and interactions within biological systems, optimizing drug delivery systems. This ensures that payloads reach their designated targets with minimal degradation, propelling the evolution of next-generation therapeutics and advancing the frontiers of pharmaceutical science.

Customized Drug Delivery: MC-VC-PAB-NH2 plays a pivotal role in tailoring drug delivery platforms for specific medical conditions, offering a personalized approach to treatment. By allowing precise control over drug release and targeting, it facilitates the creation of therapies customized to individual patient needs.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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