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CAS No.: 557756-85-1
Cat No.: BADC-01135
Purity: ≥95%
4.5 
Fmoc-N-amido-PEG4-propionic acid is a bifunctional PEG linker for ADC construction, offering improved aqueous solubility and flexible conjugation strategies in targeted drug delivery.
Structure of 557756-85-1
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| 5 g | $376 | In stock |
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Popular Publications Citing BOC Sciences Products
Fmoc-N-amido-PEG4-propionic acid is a high-performance ADC linker extensively applied in antibody-drug conjugate development. Its structure incorporates a PEG4 spacer, which provides controlled flexibility and hydrophilicity, facilitating improved conjugation efficiency between monoclonal antibodies and ADC cytotoxins. The Fmoc-protected amido group enables selective coupling in solid-phase synthesis and bioconjugation procedures, ensuring precise attachment of payloads while maintaining chemical stability under physiological conditions.
In ADC linker design, the PEG4 segment of Fmoc-N-amido-PEG4-propionic acid reduces steric hindrance between the antibody and ADC payload, enhancing accessibility of the cytotoxin and maintaining the antigen-binding capacity of the antibody. This linker is compatible with a variety of cytotoxic payloads, including microtubule inhibitors and DNA-damaging agents, making it suitable for constructing ADCs with defined drug-to-antibody ratios (DAR) and reproducible pharmacokinetic properties.
The chemical characteristics of Fmoc-N-amido-PEG4-propionic acid support site-specific conjugation strategies, enabling controlled ADC payload placement and consistent linker stability. Its hydrophilic PEG4 segment improves solubility and reduces aggregation, which is critical for ADC formulation, storage, and delivery. The linker’s stability ensures that the ADC remains intact in circulation, allowing the cytotoxic payload to reach the target tumor microenvironment effectively.
This ADC linker is widely used in oncology-focused bioconjugation applications, where the combination of PEG4 flexibility, Fmoc-protected functionality, and chemical robustness facilitates the design of ADCs with reliable therapeutic performance. Fmoc-N-amido-PEG4-propionic acid provides a standardized, reproducible tool for precise antibody-to-payload conjugation in advanced ADC research and development.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01153 | Fmoc-N-amido-PEG8-propionic acid | 756526-02-0 | |
| BADC-01171 | Fmoc-N-amido-PEG3-propionic acid | 867062-95-1 | |
| BADC-01179 | Fmoc-N-amido-PEG2-propionic acid | 872679-70-4 | |
| BADC-01185 | Fmoc-N-amido-PEG6-propionic acid | 882847-34-9 |
What is Fmoc-N-amido-PEG4-propionic acid?
Fmoc-N-amido-PEG4-propionic acid is a PEGylated linker used in ADC and peptide conjugation. The Fmoc-protected amide facilitates controlled attachment to biomolecules, while the PEG4 spacer improves solubility and reduces steric hindrance, supporting versatile research applications.
19/10/2017
Dear BOC Sciences, could you advise how Fmoc-N-amido-PEG4-propionic acid should be stored?
It should be stored in a dry, cool, and dark environment, ideally under inert gas. This prevents moisture-induced hydrolysis of the PEG linker and maintains integrity for reliable experimental use in conjugation and ADC research.
13/12/2019
Dear BOC Sciences, could you please provide the specifications of Fmoc-N-amido-PEG4-propionic acid?
Specifications include molecular weight, PEG spacer length, and Fmoc protection, which guide conjugation strategy. These parameters are provided to support precise experimental design without disclosing purity information.
10/9/2018
Could you please confirm if support documents are available for Fmoc-N-amido-PEG4-propionic acid?
Yes, it is supplied with structural data, handling protocols, and storage guidelines. Researchers can use these documents to ensure proper conjugation and reproducibility in ADC or peptide research workflows.
4/8/2016
Dear team, how is the quality of Fmoc-N-amido-PEG4-propionic acid verified?
Quality is confirmed using NMR, LC-MS, and HPLC analyses to validate chemical structure and stability. These tests ensure the linker meets research requirements for conjugation experiments and ADC development.
17/5/2022
— Dr. Olivia Brown, Senior Researcher (UK)
Fmoc-N-amido-PEG4-propionic acid arrived with excellent purity, which was crucial for our peptide-ADC conjugation studies.
10/9/2018
— Mr. David Wilson, Chemistry Scientist (USA)
The product met all our analytical specifications, and the Fmoc-N-amido-PEG4-propionic acid performed reliably in our coupling reactions.
17/5/2022
— Dr. Sofia Rossi, Biochemist (Italy)
We appreciated the prompt delivery of Fmoc-N-amido-PEG4-propionic acid. Its stability under our reaction conditions was outstanding.
4/8/2016
— Ms. Hannah Schmidt, ADC Scientist (Germany)
This linker enabled smooth PEGylation in our ADC constructs. Batch quality and reproducibility were top-notch.
19/10/2017
— Dr. Mark Taylor, Bioconjugation Specialist (Canada)
Fmoc-N-amido-PEG4-propionic acid simplified our conjugation protocol, and the product documentation was thorough and helpful.
— Dr. Isabella Lee, Senior Scientist (USA)
Excellent technical support helped us optimize the use of Fmoc-N-amido-PEG4-propionic acid, ensuring reproducible peptide-ADC yields.
13/12/2019
Fmoc-N-amido-PEG4-propionic acid
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Fmoc-N-amido-PEG4-propionic acid
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