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Fmoc-NH-PEG6-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01185 | -- | $-- | Inquiry |
Fmoc-N-amido-PEG6-propionic acid is a bifunctional linker widely used in peptide and protein chemistry. Here are some key applications of Fmoc-N-amido-PEG6-propionic acid:
Peptide Synthesis: Fmoc-N-amido-PEG6-propionic acid is used as a spacer in solid-phase peptide synthesis (SPPS) to introduce flexibility between peptide chains. The PEG6 moiety provides hydrophilicity and helps in solubilizing peptide sequences. This can improve the overall yield and purity of synthesized peptides, especially those prone to aggregation.
Drug Delivery Systems: This compound is employed in the design of advanced drug delivery systems, where the PEG6 linker helps in modulating the pharmacokinetics of the drug. By attaching to therapeutic molecules, the PEG6 spacer can enhance solubility, reduce immunogenicity, and increase the circulation time in the bloodstream. This can lead to more effective and sustained drug release profiles.
Bioconjugation: Fmoc-N-amido-PEG6-propionic acid is instrumental in bioconjugation techniques used to link peptides or proteins to other biomolecules or surfaces. The PEG6 linker acts as a flexible bridge that can reduce steric hindrance and maintain the biological activity of conjugated molecules. This is especially useful in the development of biosensors, imaging agents, and therapeutic conjugates.
Protein Engineering: In protein engineering, this linker is used to modify and stabilize proteins by attaching functional groups or polymers. The PEG6 spacer can enhance protein solubility and stability under various conditions, thus extending their shelf-life and functionality. This application is crucial for producing high-quality proteins for research, diagnostics, and therapeutic purposes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
