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Fmoc-N-amido-PEG2-propionic acid

  CAS No.: 872679-70-4   Cat No.: BADC-01179   Purity: ≥95% 4.5  

Featuring a short PEG2 chain and Fmoc protection, Fmoc-N-amido-PEG2-propionic acid enhances site-specific conjugation in ADCs. Its design improves solubility and stability, supporting effective therapeutic payload delivery in antibody-drug conjugates.

Fmoc-N-amido-PEG2-propionic acid

Structure of 872679-70-4

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Category
ADC Linker
Molecular Formula
C22H25NO6
Molecular Weight
399.44
Shipping
Room temperature
Shipping
Store at 2-8°C

* For research and manufacturing use only. We do not sell to patients.

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Synonyms
Fmoc-N-amido-PEG2-acid; Fmoc-9-Amino-4,7-Dioxanonanoic acid; 1-(9H-Fluoren-9-yl)-3-oxo-2,7,10-trioxa-4-azatridecan-13-oic acid; Fmoc-AEEP-OH; 13-(9H-Fluoren-9-yl)-11-oxo-4,7,12-trioxa-10-azatridecanoic Acid;?Fmoc-NH-PEG2-CH2CH2COOH; 9-(Fmoc-amino)-4,7-dioxanonanoic Acid; 2,7,10-Trioxa-4-azatridecan-13-oic acid, 1-(9H-fluoren-9-yl)-3-oxo-; Fmoc-NH-PEG2-COOH; Fmoc-NH-PEG2-acid; Fmoc-PEG2-propionic acid; 3-[2-[2-(Fmoc-amino)ethoxy]ethoxy]propionic Acid; 9-(9H-Fluorene-9-ylmethoxycarbonylamino)-4,7-dioxanonanoic acid
IUPAC Name
3-[2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethoxy]ethoxy]propanoic acid
Canonical SMILES
C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NCCOCCOCCC(=O)O
InChI
InChI=1S/C22H25NO6/c24-21(25)9-11-27-13-14-28-12-10-23-22(26)29-15-20-18-7-3-1-5-16(18)17-6-2-4-8-19(17)20/h1-8,20H,9-15H2,(H,23,26)(H,24,25)
InChIKey
QWHLFJJLRVOHTM-UHFFFAOYSA-N
Density
1.243±0.06 g/cm3 at 20°C, 760 Torr
Solubility
Soluble in DMSO, Methanol
Melting Point
95.0-99.0°C
Flash Point
330.0±31.5 °C
Index Of Refraction
1.584
PSA
97.58000
Vapor Pressure
0.0±1.9 mmHg at 25°C
Appearance
Colorless Oily Matter
Shipping
Room temperature
Storage
Store at 2-8°C
Pictograms
Irritant
Signal Word
Warning
Boiling Point
622.1±55.0°C at 760 mmHg
Biological Activity
Fmoc-NH-PEG2-CH2CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Historical Records: 3-Azido-N-Boc-D-Alanine | DC-1 | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate | (2,5-dioxopyrrolidin-1-yl) 4-(methyldisulfanyl)pentanoate | (2,5-dioxopyrrolidin-1-yl) 4-methyl-4-(methyldisulfanyl)pentanoate | (2,5-dioxopyrrolidin-1-yl) 4-(methyldisulfanyl)butanoate | Biotin-PEG4-PFP ester | Zilovertamab vedotin | CL2A-Chimmitecan | Fmoc-N-amido-PEG2-propionic acid | MC-VC-PABC-MMAE
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