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CAS No.: 1059588-19-0
Cat No.: BADC-00884
Purity: ≥95%
4.5 
m-PEG8-Ms is a mesylate-activated PEG linker used in antibody-drug conjugates for efficient nucleophilic substitution reactions. Its PEG8 spacer increases hydrophilicity and solubility of payloads, improving bioconjugate stability and pharmacokinetic profiles in targeted therapies.
Structure of 1059588-19-0
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Popular Publications Citing BOC Sciences Products
m-PEG8-Ms, a polyethylene glycol derivative widely utilized in biochemical and pharmaceutical realms, finds diverse applications.
Drug Delivery Systems: In the realm of drug delivery, m-PEG8-Ms plays a pivotal role in enhancing the solubility and stability of pharmaceuticals. By conjugating polyethylene glycol chains to drug molecules, it elevates their bioavailability and extends their circulation time within the bloodstream.
Protein Conjugation: Within the domain of protein chemistry, m-PEG8-Ms is a cornerstone for pegylation, a process involving the attachment of PEG moieties to proteins. This innovative procedure serves to diminish immunogenicity and prolong the half-life of therapeutic proteins and peptides.
Biocompatible Coatings: Leveraging the hydrophilic properties of PEG, m-PEG8-Ms finds application in forming biocompatible coatings on medical devices and implants. These coatings effectively mitigate protein adsorption and cell adhesion, thereby reducing the risk of immune responses and infections.
Nanoparticle Functionalization: For the functionalization of nanoparticles in diagnostic and therapeutic applications, m-PEG8-Ms emerges as a crucial player. By modifying nanoparticle surfaces with PEG chains, it enhances their stability and biocompatibility in biological settings, leading to the creation of nanoformulations tailored for targeted drug delivery and cutting-edge imaging technologies.
m-PEG8-Ms
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m-PEG8-Ms
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