Name: m-PEG4-Ms
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

2,5,8,11-tetraoxatridecan-13-yl methanesulfonate

IUPAC Name

2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl methanesulfonate

Canonical SMILES

COCCOCCOCCOCCOS(=O)(=O)C

InChI

InChI=1S/C10H22O7S/c1-13-3-4-14-5-6-15-7-8-16-9-10-17-18(2,11)12/h3-10H2,1-2H3

InChIKey

GXMYCEJMFZMVSC-UHFFFAOYSA-N

Solubility

10 mm in DMSO

Shelf Life

-20°C 3 years powder; -80°C 2 years in solvent

Shipping

Room temperature, or blue ice upon request.

Storage

Store at -20 °C, keep in dry and avoid sunlight.

m-PEG4-Ms, a methanesulfonate functionalized polyethylene glycol derivative, plays a pivotal role in bioconjugation and pharmaceutical realms. Here are four key applications of m-PEG4-Ms:

Bioconjugation: Serving as a versatile linker in bioconjugation techniques, m-PEG4-Ms facilitates the attachment of drugs or proteins to a myriad of substrates such as polymers, nanoparticles, or other surfaces. This structural modification enhances the stability, solubility, and bioavailability of therapeutic molecules, thereby elevating their efficacy to new heights. The methanesulfonate group allows for precise and efficient covalent bonding with biological entities under mild conditions, ensuring targeted interactions at a molecular level.

Drug Delivery: In the domain of drug delivery systems, m-PEG4-Ms takes center stage in the creation of prodrugs or the optimization of drug formulations to enhance pharmacokinetics and mitigate immunogenic responses. Through conjugation with m-PEG4-Ms, drug molecules can prolong their circulation within the bloodstream, affording controlled and sustained release dynamics that amplify therapeutic outcomes while minimizing adverse effects. This strategic approach enables the precise targeting of active pharmaceutical ingredients, ushering in a new era of tailored and efficacious medication delivery.

Nanotechnology: The versatile utility of m-PEG4-Ms extends into the realm of nanotechnology, where it finds application in the synthesis of PEGylated nanoparticles for diverse biomedical purposes, including imaging and targeted drug delivery. By appending polyethylene glycol chains, nanoparticles acquire enhanced biocompatibility and extended circulation times, mitigating immune recognition and subsequent clearance processes.

Surface Modification: In the realm of materials science, m-PEG4-Ms emerges as a key player in surface modification for biomedical devices, implants, and biosensors. Through the grafting of m-PEG4-Ms onto surfaces, researchers can curtail protein adsorption and cell adhesion, culminating in augmented biocompatibility and decreased fouling tendencies. This targeted application is indispensable for engineering surfaces with bespoke characteristics suited for a wide spectrum of medical and bioanalytical applications, underscoring the critical role of m-PEG4-Ms in advancing biotechnological frontiers.