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m-PEG7-CH2CH2CHO

  CAS No.: 1234369-95-9   Cat No.: BADC-00904   Purity: 98.0% 4.5  

m-PEG7-CH2CH2CHO features a PEG7 linker with terminal aldehyde functionality, enabling selective oxime ligation in ADC synthesis. This linker improves conjugation specificity and stability for targeted antibody-drug conjugate payload delivery.

m-PEG7-CH2CH2CHO

Structure of 1234369-95-9

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Category
ADC Linker
Molecular Formula
C18H36O9
Molecular Weight
396.47
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
m-PEG8-aldehyde; M-PEG8-CHO; Alpha-Methoxy-omega-propanal octa(ethylene glycol)
IUPAC Name
3-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanal
Canonical SMILES
COCCOCCOCCOCCOCCOCCOCCOCCC=O
InChI
InChI=1S/C18H36O9/c1-20-5-6-22-9-10-24-13-14-26-17-18-27-16-15-25-12-11-23-8-7-21-4-2-3-19/h3H,2,4-18H2,1H3
InChIKey
VWFQSSVTZOVAOM-UHFFFAOYSA-N
Solubility
10 mm in DMSO
PSA
90.91000
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
Room temperature
Storage
Store at -5°C,keep in dry and avoid sunlight.

m-PEG7-CH2CH2CHO, a small molecule frequently employed as a functional linker in diverse bioscience and pharmaceutical settings, finds utility in various applications.

Drug Delivery Systems: Within drug conjugation processes, m-PEG7-CH2CH2CHO plays a pivotal role in enhancing the solubility and stability of therapeutic agents. Serving as a critical linker, it facilitates the attachment of drugs to polymers, thereby augmenting their circulation time and bioavailability. This structural modification is indispensable for crafting more efficacious drug delivery systems capable of targeting specific tissues or cells with precision.

Bioconjugation: At the intersection of chemistry and biology, m-PEG7-CH2CH2CHO finds application in bioconjugation to alter proteins, antibodies, and other biomolecules. Leveraging the aldehyde group within m-PEG7-CH2CH2CHO, stable linkages can be forged with amines on biomolecules, enabling site-specific labeling or immobilization.

Surface Modification: In the domain of biotechnology and medical devices, m-PEG7-CH2CH2CHO serves as a key player in surface modification processes. By engaging with substrates, it imparts non-fouling and hydrophilic characteristics to surfaces, effectively curtailing protein adsorption and cell adhesion. This attribute proves advantageous in the creation of biocompatible surfaces ideal for implants and sensor technologies.

Nanoparticle Functionalization: In the world of nanotechnology, m-PEG7-CH2CH2CHO assumes a crucial role in the functionalization of nanoparticles, heightening their biocompatibility and stability within biological environments. Harnessing its PEG moiety, it bestows a stealth effect upon nanoparticles, diminishing immunogenicity and prolonging their circulation within the body. This advancement lays the foundation for the successful development of nanoparticles tailored for precise drug delivery and imaging applications, pushing forward the frontier of nanomedicine.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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