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CAS No.: 110429-45-3
Cat No.: BADC-00890
Purity: ≥95%
4.5 
mPEG4-bromide is a PEG linker containing a bromide group. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
Structure of 110429-45-3
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mPEG4-bromide is a versatile chemical compound widely used in biochemical research and pharmaceutical applications. Here are some key applications of mPEG4-bromide:
Protein Modification: mPEG4-bromide is commonly used to modify proteins through a process called PEGylation, which involves attaching polyethylene glycol (PEG) chains to proteins. This modification enhances protein stability, solubility, and circulation time in the body, making it valuable for therapeutic protein development. PEGylated proteins exhibit reduced immunogenicity and improved pharmacokinetics, essential for effective drug delivery.
Drug Delivery Systems: In pharmaceutical applications, mPEG4-bromide is employed to create novel drug delivery systems. By conjugating with drug molecules, mPEG4-bromide enhances the solubility and bioavailability of hydrophobic drugs. This approach facilitates the design of targeted therapies with controlled release profiles, optimizing drug efficacy and patient outcomes.
Surface Coating: mPEG4-bromide is utilized in the development of biocompatible surface coatings for medical devices. By coating surfaces with PEG, it reduces protein adsorption and minimizes immune responses, ensuring compatibility with the human body. These properties are crucial for the performance and longevity of implants, catheters, and other medical devices.
Diagnostic Assays: In the field of diagnostics, mPEG4-bromide is used to modify biomolecules for use in various assays and detection systems. It can improve the sensitivity and specificity of diagnostic tests by reducing nonspecific binding and enhancing signal detection. This makes it an invaluable tool in the development of reliable and accurate diagnostic platforms.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00875 | m-PEG6-SS-PEG6-methyl | 1007386-15-3 | |
| BADC-00512 | m-PEG1-NHS ester | 1027371-75-0 | |
| BADC-00878 | mPEG6-azide | 1043884-49-6 | |
| BADC-00882 | m-PEG5-succinimidyl carbonate | 1058691-00-1 | |
| BADC-00883 | mPEG7-aldehyde | 1058691-77-2 | |
| BADC-00884 | m-PEG8-Ms | 1059588-19-0 | |
| BADC-00889 | m-PEG8-COOH | 1093647-41-6 | |
| BADC-00519 | m-PEG2-NHS ester | 1127247-34-0 | |
| BADC-00904 | m-PEG7-CH2CH2CHO | 1234369-95-9 | |
| BADC-00920 | m-PEG4-Ms | 130955-37-2 |
What is mPEG4-bromide and its function in ADC development?
mPEG4-bromide is a short PEG linker terminated with a bromide group, used for nucleophilic substitution reactions to attach drugs or functional groups to antibodies. Its PEG4 spacer improves solubility and pharmacokinetics of ADCs.
8/7/2019
We would like to know how mPEG4-bromide influences ADC pharmacokinetics.
The PEG4 unit in mPEG4-bromide enhances solubility and reduces immunogenicity. It increases circulation time of ADCs and reduces rapid clearance, improving drug bioavailability and therapeutic efficacy.
22/9/2019
Could you kindly inform us which reactions are suitable for mPEG4-bromide conjugation?
mPEG4-bromide undergoes efficient nucleophilic substitution with thiol or amine groups on antibodies or payloads. This versatility allows for stable covalent attachment in ADC synthesis.
9/2/2019
Good afternoon! What precautions should be taken when handling mPEG4-bromide?
Handle mPEG4-bromide under inert atmosphere and avoid moisture. Use appropriate personal protective equipment to prevent exposure, and store in a sealed container at low temperature to maintain chemical stability.
18/9/2018
Dear team, are there any specific recommendations for preparing solutions of mPEG4-bromide?
Solutions of mPEG4-bromide should be prepared using anhydrous solvents under inert atmosphere to prevent hydrolysis. Avoid prolonged exposure to moisture and store aliquots in sealed containers at low temperature to maintain reactivity for subsequent ADC conjugation.
10/12/2022
— Dr. Oliver Brown, Senior Scientist (UK)
mPEG4-bromide showed excellent reactivity for PEGylation in our conjugation protocols.
9/2/2019
— Ms. Clara Weber, Biochemist (Germany)
High solubility and lot consistency enabled smooth multi-step synthesis.
10/12/2022
— Dr. Ethan Parker, Medicinal Chemist (USA)
Reproducible yields and minimal side reactions were achieved using this reagent.
18/9/2018
— Dr. Sophie Moreau, Senior Scientist (France)
Integration into ADC linker workflows was seamless and reliable.
8/7/2019
— Dr. Liam Fischer, Chemist (UK)
mPEG4-bromide enabled innovative linker architectures for enhanced solubility.
— Ms. Hannah Lee, Medicinal Chemist (USA)
BOC Sciences’ mPEG4-bromide enabled efficient alkylation reactions. The product arrived on schedule with high purity, supporting our experimental timeline.
22/9/2019
mPEG4-bromide
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mPEG4-bromide
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