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Mal-PEG3-PFP ester is a PEG linker containing maleimide and PFP moieties. Maleimide is thiol-reactive and reacts between pH 6.5 and 7.5 to form thiol ester bonds. PFP moiety is amine-reactive and is less susceptible to undergoing hydrolysis. The hydrophilic PEG linker increases the water solubility of a compound in aqueous media.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00713 | -- | $-- | Inquiry |
Mal-PEG3-PFP ester, a versatile chemical reagent, finds applications in a myriad of biochemical and pharmaceutical realms.
Protein Conjugation: Mal-PEG3-PFP ester emerges as a pivotal tool in protein conjugation, showcasing its prowess in modifying amino groups within proteins. Through interactions with lysine residues, this compound facilitates the attachment of polyethylene glycol (PEG) chains, thereby augmenting protein solubility and stability. This modification plays a critical role in elevating the therapeutic potential of protein-based medications while mitigating immunogenic responses.
Surface Modification: Delving into surface modification, researchers harness the power of Mal-PEG3-PFP ester to create PEGylated surfaces on various substrates like nanoparticles and medical devices. Coating surfaces with this compound enhances biocompatibility and reduces nonspecific protein adsorption, underpinning its utility in crafting drug delivery platforms and bolstering biosensor performance.
Crosslinking Applications: In the realm of hydrogel and biopolymer synthesis, Mal-PEG3-PFP ester shines as a favored crosslinking agent, enabling the formation of stable ester linkages that give rise to intricate network structures within polymer matrices. This capability is instrumental in tailoring materials with precise mechanical properties and degradation kinetics, fostering advancements in tissue engineering and regenerative medicine.
Drug Delivery Systems: Within the domain of pharmaceutical research, Mal-PEG3-PFP ester plays a pivotal role in functionalizing drug carriers like liposomes and micelles. Its reactivity with biological molecules allows for strategic covalent attachment of therapeutic agents, thereby enhancing targeted delivery and release profiles. This feature proves indispensable in the design of sophisticated drug delivery systems that elevate treatment efficacy and diminish adverse side effects.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
