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Mal-PEG-NHS is a bioconjugation reagent widely used in the biomedical industry. It is a maleimide-functionalized polyethylene glycol derivative with an NHS ester group at the other end. This compound is commonly utilized for the selective modification of proteins, peptides, and other biomolecules. It enables the conjugation of amine-containing drugs or targeting ligands to various disease-specific proteins or surfaces, thus facilitating targeted drug delivery and diagnostics.
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-00448 | -- | $-- | Inquiry |
Mal-PEG-NHS is a versatile reagent used extensively in bioconjugation applications, particularly for the attachment of various biomolecules to surfaces or other molecules. The compound features a maleimide (Mal) group, which enables selective conjugation to thiol-containing molecules such as proteins, antibodies, or peptides. The polyethylene glycol (PEG) spacer improves solubility, stability, and biocompatibility, while the NHS (N-hydroxysuccinimide) ester group facilitates efficient coupling with amine-containing biomolecules, making this reagent ideal for applications in drug delivery, diagnostics, and molecular labeling.
A key application of Mal-PEG-NHS is in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy. In this context, the NHS ester reacts with amine groups on monoclonal antibodies, allowing for the attachment of cytotoxic drugs or therapeutic molecules. The maleimide group facilitates conjugation to thiol-containing molecules, such as antibodies or peptides, while the PEG spacer ensures increased solubility and improved pharmacokinetics. This results in the enhanced stability of the conjugate in circulation and the targeted delivery of potent therapeutic agents to tumor cells, minimizing off-target effects and improving efficacy.
Mal-PEG-NHS is also widely used in diagnostic applications, particularly in the development of imaging agents and biosensors. By coupling imaging molecules to antibodies or peptides via the NHS ester group, Mal-PEG-NHS enables the precise targeting of disease biomarkers. The PEG spacer ensures solubility and reduces nonspecific binding, improving the sensitivity and accuracy of diagnostic assays. This is particularly valuable in molecular imaging techniques such as PET (positron emission tomography) or fluorescence-based imaging, where targeted and stable conjugates are essential for reliable detection of diseases such as cancer.
In addition to drug delivery and diagnostics, Mal-PEG-NHS is used in the functionalization of surfaces for biosensor applications. By attaching biomolecules, such as proteins or nucleic acids, to solid surfaces or nanoparticles via the maleimide group, Mal-PEG-NHS enables the development of highly sensitive biosensors. The PEG spacer reduces steric hindrance, allowing for efficient binding of the target biomolecule, while improving the stability and reproducibility of the sensor’s performance. This application is critical for the development of advanced diagnostic tools, including point-of-care devices and personalized medicine technologies.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, non-natural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
