Aminooxy-PEG2-bis-PEG3-BCN

Aminooxy-PEG2-bis-PEG3-BCN is a multifunctional linker used in bioconjugation and crosslinking applications. Here are some key applications of Aminooxy-PEG2-bis-PEG3-BCN:

Bioconjugation: Aminooxy-PEG2-bis-PEG3-BCN is used in the specific attachment of biomolecules through oxime chemistry. This allows for the stable and site-specific conjugation of proteins, peptides, and other ligands to surfaces or other biomolecules. It facilitates the creation of complex bioconjugates for applications such as drug delivery, diagnostic assays, and biomaterial engineering.

Drug Delivery Systems: In drug delivery, Aminooxy-PEG2-bis-PEG3-BCN can be used to attach therapeutic agents to nanoparticles or polymers. The poly(ethylene glycol) (PEG) chains enhance solubility and circulation time, while the BCN (bicyclo[6.1.0]nonyne) group enables efficient conjugation through bioorthogonal click chemistry. This results in improved targeting and release profiles for drug delivery systems.

Immunoassays: Aminooxy-PEG2-bis-PEG3-BCN is valuable in the development of immunoassays where it is used to conjugate antigens or antibodies to various surfaces. This enhances the sensitivity and specificity of assays for detecting proteins, pathogens, or other analytes. The stable linkage provided by oxime chemistry ensures reliable performance in diagnostic tests.

Biomaterial Functionalization: Aminooxy-PEG2-bis-PEG3-BCN is used to functionalize biomaterials such as hydrogels and nanoparticles with bioactive molecules. This facilitates the creation of biofunctional surfaces that can interact with cells, proteins, and other biological entities. Applications include tissue engineering, regenerative medicine, and the development of biosensors.