Amino-PEG5-alcohol - CAS 34188-11-9

Amino-PEG5-alcohol - CAS 34188-11-9 Catalog number: BADC-01117

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NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Amino-PEG5-alcohol
CAS
34188-11-9
Catalog Number
BADC-01117
Molecular Formula
C10H23NO5
Molecular Weight
237.29
Amino-PEG5-alcohol

Ordering Information

Catalog Number Size Price Quantity
BADC-01117 -- $--
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Description
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
NH2-PEG5-OH; 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
IUPAC Name
2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethanol
Canonical SMILES
C(COCCOCCOCCOCCO)N
InChI
InChI=1S/C10H23NO5/c11-1-3-13-5-7-15-9-10-16-8-6-14-4-2-12/h12H,1-11H2
InChIKey
DEOUHEFHTMMUCM-UHFFFAOYSA-N
Density
1.1±0.0 g/cm3
Solubility
Soluble in DMSO (10 mm)
Flash Point
163.2±0.0 °C
Index Of Refraction
1.460
LogP
-2.44
Vapor Pressure
0.0±0.0 mmHg at 25°C
Biological Activity
NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a noncleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1] . ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .
Appearance
Pale Yellow or Colorless Oily Matter
Purity
≥95%
Shipping
Room temperature, or blue ice upon request.
Storage
Store at 2-8°C
Boiling Point
346.3±0.0 °C at 760 mmHg
Form
Solid
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Propargyl-PEG2-acid | Amino-PEG5-alcohol
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