Amino-PEG4-alcohol - CAS 86770-74-3

Amino-PEG4-alcohol - CAS 86770-74-3 Catalog number: BADC-01174

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Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Category
ADCs Linker
Product Name
Amino-PEG4-alcohol
CAS
86770-74-3
Catalog Number
BADC-01174
Molecular Formula
C8H19NO4
Molecular Weight
193.24
Amino-PEG4-alcohol

Ordering Information

Catalog Number Size Price Quantity
BADC-01174 -- $--
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Description
Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Synonyms
2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol; 1-Amino-3,6,9-Trioxaundecanyl-11-ol
IUPAC Name
2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol
Canonical SMILES
C(COCCOCCOCCO)N
InChI
InChI=1S/C8H19NO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-9H2
InChIKey
ANOJXMUSDYSKET-UHFFFAOYSA-N
Density
1.1±0.1 g/cm3
Solubility
Soluble in Water (50 mg/ml; 25875 mm; need ultrasonic)
Flash Point
136.2±23.7 °C
Index Of Refraction
1.459
LogP
-2.09
PSA
73.94000
Vapor Pressure
0.0±1.4 mmHg at 25°C
Biological Activity
Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .
Appearance
Pale Yellow Oily Matter
Purity
≥95%
Shipping
Room temperature
Storage
Store at 2-8°C
Pictograms
Corrosive; Irritant
Signal Word
Danger
Boiling Point
301.6±27.0 °C at 760 mmHg
Form
Solid
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Amino-PEG4-alcohol
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