Name: Amino-PEG4-alcohol
Brand: BOC Sciences
Rating: 5 (1 reviews)

Synonyms

2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethanol; 1-Amino-3,6,9-Trioxaundecanyl-11-ol

IUPAC Name

2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanol

Canonical SMILES

C(COCCOCCOCCO)N

InChI

InChI=1S/C8H19NO4/c9-1-3-11-5-7-13-8-6-12-4-2-10/h10H,1-9H2

InChIKey

ANOJXMUSDYSKET-UHFFFAOYSA-N

Density

1.1±0.1 g/cm3

Solubility

Soluble in Water (50 mg/ml; 25875 mm; need ultrasonic)

Flash Point

136.2±23.7 °C

Index Of Refraction

1.459

PSA

73.94000

Vapor Pressure

0.0±1.4 mmHg at 25°C

Appearance

Pale Yellow Oily Matter

Shipping

Room temperature

Storage

Store at 2-8°C

Pictograms

Corrosive; Irritant

Signal Word

Danger

Boiling Point

301.6±27.0 °C at 760 mmHg

Form

Solid

Biological Activity

Amino-PEG4-alcohol is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Amino-PEG4-alcohol is also a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2] . In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2] .

Amino-PEG4-alcohol is a versatile compound employed in various biotechnological, pharmaceutical, and material science applications. Here are some key applications of Amino-PEG4-alcohol:

Protein PEGylation: Amino-PEG4-alcohol is used for the PEGylation of therapeutic proteins, which involves attaching polyethylene glycol (PEG) chains to proteins to enhance their stability and solubility. This process helps reduce immunogenicity and prolongs the half-life of therapeutic proteins in the bloodstream. Ultimately, this leads to improved efficacy and reduced dosing frequency for protein-based therapies.

Drug Delivery Systems: Amino-PEG4-alcohol serves as a linker or spacer in the design of drug delivery systems, including nanoparticles and liposomes. Its hydrophilic nature allows for better dispersion and stability of drug carriers in aqueous environments. These systems can be engineered to achieve targeted and controlled release of drugs, enhancing therapeutic outcomes.

Bioconjugation: In bioconjugation techniques, Amino-PEG4-alcohol is often used to link biomolecules, such as antibodies, enzymes, or nucleic acids, to various surfaces or other molecules. This facilitates the creation of advanced diagnostic tools, biosensors, and bio-functional materials. The flexibility and biocompatibility of the PEG chain improve the performance and stability of the conjugated products.

Biomedical Research: Amino-PEG4-alcohol is employed in the synthesis of various biomaterials used in tissue engineering and regenerative medicine. It helps in modifying the surface properties of biomaterials to promote cell attachment, proliferation, and differentiation. This enhances the development of scaffolds and matrices that can support tissue regeneration and repair.

Catalog	Product Name	CAS
BADC-00917	Amino-PEG10-alcohol	129449-09-8
BADC-00962	Amino-PEG11-alcohol	15332-94-2
BADC-01117	Amino-PEG5-alcohol	34188-11-9
BADC-01121	Amino-PEG6-alcohol	39160-70-8