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CAS No.: 15332-94-2
Cat No.: BADC-00962
Purity: ≥95%
4.5 
Amino-PEG11-alcohol is a PEG linker containing an amino group. The amino group can react with carboxylic acids, activated NHS esters, carbonyls and so on.
Structure of 15332-94-2
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Popular Publications Citing BOC Sciences Products
Amino-PEG11-alcohol is a versatile ADC linker intermediate widely used in antibody-drug conjugate (ADC) construction and targeted bioconjugation applications. Featuring a hydrophilic PEG11 spacer, a terminal primary amine, and an alcohol group, it enables efficient and site-specific conjugation with ADC cytotoxins and monoclonal antibodies. The long PEG11 chain enhances solubility, reduces steric hindrance, and improves pharmacokinetic properties of ADC payloads. In ADC linker design, Amino-PEG11-alcohol supports modular and flexible linker construction while maintaining antibody integrity, enabling controlled intracellular delivery of cytotoxic payloads in tumor cells.
In payload conjugation applications, Amino-PEG11-alcohol is compatible with a broad range of ADC cytotoxins, including DNA-targeting agents, microtubule inhibitors, and other potent therapeutic payloads. Its terminal primary amine allows efficient coupling to activated carboxylic acids or NHS-activated linkers, while the PEG11 spacer provides flexibility and solubility, promoting homogeneous and stable ADC assembly. The alcohol group can serve as a functional handle for further chemical modifications or secondary conjugation strategies. Researchers can employ this intermediate to optimize linker length, improve intracellular payload release, and construct high-performance ADCs suitable for both preclinical research and industrial-scale production.
From an application perspective, Amino-PEG11-alcohol is widely applied in oncology-focused ADC research, protein bioconjugation studies, and advanced drug delivery systems. Its hydrophilic PEG11 chain enhances circulation time, reduces aggregation of ADC payloads, and improves pharmacokinetics. The combination of primary amine and alcohol functionality ensures flexible, predictable, and site-specific conjugation. By integrating Amino-PEG11-alcohol into ADC linker design, developers can construct stable, highly soluble, and efficient linker-payload conjugates, supporting tumor-targeted delivery and enhanced therapeutic efficacy in modern ADC development.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00917 | Amino-PEG10-alcohol | 129449-09-8 | |
| BADC-01117 | Amino-PEG5-alcohol | 34188-11-9 | |
| BADC-01121 | Amino-PEG6-alcohol | 39160-70-8 | |
| BADC-01174 | Amino-PEG4-alcohol | 86770-74-3 |
What is Amino-PEG11-alcohol and its significance in ADC linkers?
Amino-PEG11-alcohol is a bifunctional hydrophilic linker containing a terminal amine and hydroxyl group. It facilitates conjugation to both antibodies and payloads while enhancing solubility and reducing aggregation.
8/3/2019
Dear team, how does Amino-PEG11-alcohol improve ADC pharmacokinetics?
The PEG11 spacer increases hydrophilicity, improves circulation half-life, and minimizes non-specific interactions. It ensures better distribution and stability of the ADC in biological systems.
29/12/2022
Could you kindly inform us which functional groups are reactive with Amino-PEG11-alcohol?
The terminal amine reacts with activated esters, aldehydes, and isothiocyanates, while the hydroxyl group can participate in esterification or etherification reactions for versatile conjugation strategies.
18/12/2018
Dear team, what storage conditions are required for Amino-PEG11-alcohol?
Store at -20°C under inert atmosphere, protected from moisture and light. Avoid repeated freeze-thaw cycles to preserve chemical integrity and reactivity of the functional groups.
21/11/2021
Dear BOC Sciences, what are the handling and detection recommendations for Amino-PEG11-alcohol?
Amino-PEG11-alcohol should be stored at -20°C in a dry, inert environment and protected from prolonged light exposure. Detection and monitoring can be performed via HPLC or mass spectrometry to verify structural integrity. Using aliquots reduces contamination and preserves reactive amine functionality for bioconjugation applications.
29/9/2017
— Dr. Sarah Collins, Protein Chemist (USA)
Amino-PEG11-alcohol linker provided excellent solubility and flexibility for conjugation, enabling reproducible ADC synthesis.
18/12/2018
— Prof. Markus Fischer, Medicinal Chemist (Germany)
The long PEG chain reduced steric hindrance and improved payload accessibility. Highly satisfied.
29/9/2017
— Dr. Claudia Rossi, ADC Scientist (Italy)
BOC Sciences delivered Amino-PEG11-alcohol with excellent purity and consistent batch quality.
21/11/2021
— Ms. Emily Parker, R&D Manager (UK)
This PEG linker allowed smooth conjugation in aqueous buffers and minimized aggregation. Very reliable.
8/3/2019
— Dr. Henrik Larsen, Bioconjugation Specialist (Denmark)
Amino-PEG11-alcohol linker met all our analytical and solubility specifications, enhancing our workflow efficiency.
— Mr. Felix Johnson, Senior Scientist (France)
High-quality PEG linker that simplified our ADC development. Excellent communication and delivery from BOC Sciences.
29/12/2022
Amino-PEG11-alcohol
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Amino-PEG11-alcohol
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