Bis-PEG17-NHS ester

Bis-PEG17-NHS ester is a bifunctional polyethylene glycol (PEG) derivative commonly used in bioconjugation and surface modification applications. Here are some key applications of Bis-PEG17-NHS ester:

Protein Pegylation: Bis-PEG17-NHS ester is used to modify proteins by attaching PEG chains to lysine residues. This process, known as pegylation, enhances the stability, solubility, and half-life of therapeutic proteins. By reducing immunogenicity and proteolytic degradation, pegylation improves the overall efficacy of protein-based drugs.

Surface Functionalization: In sensor technologies and bioassays, Bis-PEG17-NHS ester is employed to immobilize biomolecules on solid surfaces. By linking PEG molecules to biosensors or microarrays, it creates a biocompatible and non-fouling surface. This enhances the performance and accuracy of diagnostic assays by reducing non-specific binding.

Nanoparticle Modification: Bis-PEG17-NHS ester is used to coat nanoparticles with PEG chains, providing a hydrophilic and stealthy layer. This modification reduces opsonization and prolongs the circulation time of nanoparticles in the bloodstream. It’s particularly beneficial for drug delivery systems as it enhances the targeting efficiency and bioavailability of the therapeutic agents.

Tissue Engineering: Bis-PEG17-NHS ester is utilized in the development of hydrogels and scaffolds for tissue engineering applications. By crosslinking with amino groups in the scaffold matrix, it increases the mechanical strength and stability of the constructs. This supports the growth and differentiation of cells, facilitating tissue regeneration and repair.