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Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01080 | -- | $-- | Inquiry |
Bis-PEG17-NHS ester is a bifunctional polyethylene glycol (PEG) derivative commonly used in bioconjugation and surface modification applications. Here are some key applications of Bis-PEG17-NHS ester:
Protein Pegylation: Bis-PEG17-NHS ester is used to modify proteins by attaching PEG chains to lysine residues. This process, known as pegylation, enhances the stability, solubility, and half-life of therapeutic proteins. By reducing immunogenicity and proteolytic degradation, pegylation improves the overall efficacy of protein-based drugs.
Surface Functionalization: In sensor technologies and bioassays, Bis-PEG17-NHS ester is employed to immobilize biomolecules on solid surfaces. By linking PEG molecules to biosensors or microarrays, it creates a biocompatible and non-fouling surface. This enhances the performance and accuracy of diagnostic assays by reducing non-specific binding.
Nanoparticle Modification: Bis-PEG17-NHS ester is used to coat nanoparticles with PEG chains, providing a hydrophilic and stealthy layer. This modification reduces opsonization and prolongs the circulation time of nanoparticles in the bloodstream. It’s particularly beneficial for drug delivery systems as it enhances the targeting efficiency and bioavailability of the therapeutic agents.
Tissue Engineering: Bis-PEG17-NHS ester is utilized in the development of hydrogels and scaffolds for tissue engineering applications. By crosslinking with amino groups in the scaffold matrix, it increases the mechanical strength and stability of the constructs. This supports the growth and differentiation of cells, facilitating tissue regeneration and repair.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
