Bis-PEG7-NHS ester

Bis-PEG7-NHS ester is a crosslinking reagent widely used in bioconjugation and chemical biology. Here are some key applications of Bis-PEG7-NHS ester:

Protein-Protein Conjugation: Bis-PEG7-NHS ester is commonly used to link two proteins together, forming stable protein-protein conjugates. This technique is essential for creating bifunctional proteins for research and therapeutic purposes. It allows for the study of protein interactions and the development of multi-functional biotherapeutics.

Antibody-Drug Conjugates (ADCs): In the development of targeted cancer therapies, Bis-PEG7-NHS ester is used to attach cytotoxic drugs to antibodies. By forming a stable linker between the drug and the antibody, it ensures targeted delivery of the drug to cancer cells, minimizing off-target effects. This technology is pivotal for enhancing the efficacy and specificity of cancer treatments.

Surface Modification: Bis-PEG7-NHS ester is utilized to modify surfaces of various materials, such as nanoparticles, glass, and polymers. By attaching functional groups to surfaces, it enhances biocompatibility, reduces non-specific binding, and improves the stability of biomedical devices. This application is critical for the development of biosensors, implants, and diagnostic tools.

Peptide Synthesis: In peptide synthesis, Bis-PEG7-NHS ester is employed to link peptides together or to attach peptides to other molecules. This crosslinking is crucial for creating peptide arrays, peptide-based drugs, and for studying peptide interactions. It enables the design of complex peptide structures with improved stability and functionality.