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Bis-PEG7-NHS ester is a non-cleavable 7-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-00924 | -- | $-- | Inquiry |
Bis-PEG7-NHS ester is a crosslinking reagent widely used in bioconjugation and chemical biology. Here are some key applications of Bis-PEG7-NHS ester:
Protein-Protein Conjugation: Bis-PEG7-NHS ester is commonly used to link two proteins together, forming stable protein-protein conjugates. This technique is essential for creating bifunctional proteins for research and therapeutic purposes. It allows for the study of protein interactions and the development of multi-functional biotherapeutics.
Antibody-Drug Conjugates (ADCs): In the development of targeted cancer therapies, Bis-PEG7-NHS ester is used to attach cytotoxic drugs to antibodies. By forming a stable linker between the drug and the antibody, it ensures targeted delivery of the drug to cancer cells, minimizing off-target effects. This technology is pivotal for enhancing the efficacy and specificity of cancer treatments.
Surface Modification: Bis-PEG7-NHS ester is utilized to modify surfaces of various materials, such as nanoparticles, glass, and polymers. By attaching functional groups to surfaces, it enhances biocompatibility, reduces non-specific binding, and improves the stability of biomedical devices. This application is critical for the development of biosensors, implants, and diagnostic tools.
Peptide Synthesis: In peptide synthesis, Bis-PEG7-NHS ester is employed to link peptides together or to attach peptides to other molecules. This crosslinking is crucial for creating peptide arrays, peptide-based drugs, and for studying peptide interactions. It enables the design of complex peptide structures with improved stability and functionality.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
