Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chlorotoxin binds to Cl- channels (small conductance epithelial chloride channels) in the brain and spinal cord and inhibits Cl- influx.
Structure of 163515-35-3
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Size | Price | Stock | Quantity |
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1 mg | $519 | In stock |
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Capabilities & Facilities
NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
---|---|---|---|---|---|
NCT00379132 | Breast Cancer | Phase 1 | 2009-03-31 | TransMolecular | Completed |
NCT00683761 | Malignant Glioma | Phase 1, Phase 2 | 2009-07-17 | TransMolecular | Unknown Verified July 2009 by TransMolecular. Recruitment status was Active, not recruiting |
NCT00591058 | Malignant Glioma | Phase 1 | 2009-07-17 | TransMolecular | Unknown Verified July 2009 by TransMolecular. Recruitment status was Active, not recruiting |
NCT00114309 | Malignant Glioma | Phase 2 | 2009-04-03 | TransMolecular | Unknown Verified April 2009 by TransMolecular. Recruitment status was Active, not recruiting |
NCT04214392 | Recurrent Glioblastoma | Phase 1 | 2021-06-15 | City of Hope Medical Center | Recruiting |
Chlorotoxin is a 36-amino-acid peptide derived from scorpion venom and has emerged as a potential ADC cytotoxin in the design of antibody-drug conjugates. As an ADC payload, Chlorotoxin selectively binds to matrix metalloproteinase-2 (MMP-2) and chloride channels overexpressed on tumor cells, enabling targeted delivery of cytotoxic effects. Its high tumor selectivity and low systemic toxicity make it a promising candidate for precision oncology applications.
Within antibody-drug conjugates, Chlorotoxin can be conjugated to monoclonal antibodies or other targeting scaffolds via cleavable or non-cleavable linkers. Upon binding and internalization, the payload mediates inhibition of ion channels and disrupts tumor cell invasiveness and proliferation. This tumor-specific mechanism allows ADCs incorporating Chlorotoxin to deliver cytotoxic or anti-invasive effects directly to malignant cells, minimizing off-target damage and enhancing therapeutic index.
Applications of Chlorotoxin in ADC development include targeting gliomas, neuroblastomas, and other MMP-2 overexpressing solid tumors. Its peptide nature allows chemical modification for enhanced stability, linker compatibility, and conjugation efficiency. Researchers are exploring Chlorotoxin-based ADCs to improve tumor penetration, reduce systemic exposure, and exploit its dual function as both a targeting moiety and cytotoxic agent, supporting the creation of next-generation, precision-targeted antibody-drug conjugates.
What is Chlorotoxin?
Chlorotoxin is a peptide-based cytotoxin derived from scorpion venom and is utilized in ADCs for selective targeting. It binds specifically to chloride channels or matrix metalloproteinase-2, facilitating targeted delivery of cytotoxic payloads.
29/1/2022
Could you kindly explain how Chlorotoxin is applied in ADC development?
Chlorotoxin is conjugated to antibodies to selectively direct cytotoxic agents to cells expressing relevant channels or enzymes. This targeted approach enhances therapeutic efficiency while minimizing effects on non-target tissues.
13/9/2020
We are interested in knowing which linkers are appropriate for Chlorotoxin ADCs.
Chlorotoxin can be conjugated via cleavable linkers for intracellular payload release or non-cleavable linkers for improved systemic stability. Linker choice is guided by desired release kinetics and pharmacological profile.
25/12/2022
Could you please let me know what precautions should be observed when handling Chlorotoxin?
Due to its biological activity, Chlorotoxin must be handled using standard biosafety procedures, including PPE and containment measures, to prevent accidental exposure during conjugation and experimental workflows.
3/10/2021
Good afternoon! What advantages do Chlorotoxin ADCs offer?
Chlorotoxin ADCs enable targeted cytotoxicity toward specific cellular markers, improving therapeutic indices and allowing more precise preclinical research. They facilitate selective drug delivery in oncology and neurological disease models.
9/27/2019
— Dr. Kevin Wallace, Senior Scientist (USA)
Chlorotoxin from BOC Sciences arrived with excellent purity, supporting our ADC projects seamlessly.
25/12/2022
— Dr. Jonathan Reed, Oncology Scientist (USA)
We sourced Chlorotoxin from BOC Sciences for our tumor-targeting studies. The compound showed remarkable stability and bioactivity, making our experimental design far more reliable.
9/27/2019
— Dr. Hans Bauer, Medicinal Chemist (Germany)
Fast delivery and detailed QC documentation for Chlorotoxin ensured project continuity.
3/10/2021
— Dr. Helen Brooks, Senior Research Scientist (UK)
Chlorotoxin from BOC Sciences integrated smoothly into our targeting experiments. The compound displayed excellent consistency across multiple assay conditions, giving us confidence in data reproducibility.
29/1/2022
— Dr. Richard Moore, Lead Scientist (USA)
High-purity Chlorotoxin and timely delivery boosted our ADC assay performance.
— Dr. Michael Turner, Biomedical Research Scientist (USA)
We needed Chlorotoxin quickly for our peptide-targeting research, and BOC Sciences delivered on schedule. The compound maintained high purity and was supported by transparent analytical data.
13/9/2020
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