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Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death.
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| BADC-00593 | -- | $-- |
| NCT Number | Condition Or Disease | Phase | Start Date | Sponsor | Status |
|---|---|---|---|---|---|
| NCT01469221 | Bladder Cancer | Phase 3 | 2017-12-15 | Spectrum Pharmaceuticals, Inc | Terminated (Business reason) |
| NCT00141531 | Bladder Neoplasms | Phase 2 | 2012-06-14 | Spectrum Pharmaceuticals, Inc | Completed |
| NCT00461591 | Bladder Cancer | Phase 3 | 2021-03-30 | Spectrum Pharmaceuticals, Inc | Completed |
| NCT02563561 | Bladder Cancer | Phase 3 | 2021-10-27 | Spectrum Pharmaceuticals, Inc | Terminated |
| NCT03224182 | Bladder Cancer | Phase 3 | 2021-09-28 | Spectrum Pharmaceuticals, Inc | Terminated (Suspended development) |
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
