Apaziquone - CAS 141304-51-0

Apaziquone - CAS 141304-51-0 Catalog number: BADC-00593

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Apaziquone is an indolequinone bioreductive prodrug and analog of mitomycin C with potential antineoplastic and radiosensitization activities. Apaziquone is converted to active metabolites in hypoxic cells by intracellular reductases, which are present in greater amounts in hypoxic tumor cells. The active metabolites alkylate DNA, resulting in apoptotic cell death.

General Information

Category
ADCs Cytotoxin
Product Name
Apaziquone
CAS
141304-51-0
Catalog Number
BADC-00593
Molecular Formula
C15H18O3
Molecular Weight
246.3

Chemical Structure

  • Apaziquone
Synonyms
1H-INDOLE-4,7-DIONE, 5-(1-AZIRIDINYL)-3-(HYDROXYMETHYL)-2-(3-HYDROXY-1-PROPENYL)-1-METHYL-, (E)-; APAZIQUONE
Shipping
Room temperature

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