Hydroxy-PEG2-t-butyl ester - CAS 133803-81-3

Hydroxy-PEG2-t-butyl ester - CAS 133803-81-3 Catalog number: BADC-00926

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Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196).

Category
ADCs Linker
Product Name
Hydroxy-PEG2-t-butyl ester
CAS
133803-81-3
Catalog Number
BADC-00926
Molecular Formula
C11H22O5
Molecular Weight
234.29
Purity
≥95%
Hydroxy-PEG2-t-butyl ester

Ordering Information

Catalog Number Size Price Quantity
BADC-00926 -- $-- Inquiry
Description
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2-(CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196).
Synonyms
HO-PEG2-CH2CH2COOtBu; Hydroxy-PEG2-(CH2)2-Boc; OH-PEG2-TBA; OH-PEG2-CH2CH2COOtBu; HO-PEG2-t-butyl ester; Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester; t-Butyl 9-hydroxy-4,7-dioxanonanoate; 3-[2-(2-hydroxyethoxy)ethoxy]propionic acid t-butyl ester; 2-Methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
IUPAC Name
tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate
Canonical SMILES
CC(C)(C)OC(=O)CCOCCOCCO
InChI
InChI=1S/C11H22O5/c1-11(2,3)16-10(13)4-6-14-8-9-15-7-5-12/h12H,4-9H2,1-3H3
InChIKey
OKOWESVURLUVMD-UHFFFAOYSA-N
Density
1.046±0.1 g/cm3
Solubility
Soluble in DMSO (10 mm)
LogP
0.74370
PSA
64.99000
Appearance
Pale Yellow or Colorless Oily Liquid
Shipping
Room temperature
Storage
Store at 2-8°C
Boiling Point
321.8±22.0 °C at 760 mmHg
Biological Activity
Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2- (CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Hydroxy-PEG2-t-butyl ester, a versatile compound utilized as a polyethylene glycol (PEG) derivative in bioscience, finds numerous applications.

Drug Delivery: Integrated extensively into drug delivery systems, Hydroxy-PEG2-t-butyl ester plays a pivotal role in enhancing the solubility and bioavailability of therapeutic agents. By conjugating drugs with this PEG derivative, researchers can significantly improve drug stability while simultaneously reducing immunogenicity. This innovative approach enables the delivery of more potent and precisely targeted treatments, thereby minimizing adverse side effects.

Surface Modification: Acting as a crucial element in surface modification techniques used on nanoparticles and medical devices, this compound enhances hydrophilicity and biocompatibility by attaching to surfaces. The reduction in protein adsorption and cellular adhesion achieved through this application is instrumental in developing long-circulating nanoparticles and anti-fouling coatings for implants.

Protein Conjugation: In the domain of protein conjugation, Hydroxy-PEG2-t-butyl ester emerges as a key player in extending the half-life of therapeutic proteins in the bloodstream. PEGylation of proteins with this compound significantly enhances pharmacokinetics while reducing susceptibility to degradation by proteolytic enzymes.

Diagnostic Imaging: Within diagnostic imaging, the utilization of Hydroxy-PEG2-t-butyl ester is indispensable in improving the performance of imaging agents. By PEGylating contrast agents or molecular probes, researchers can enhance solubility and prolong circulation time, leading to heightened imaging precision and diagnostic accuracy.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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