Inquiry Basket
CAS No.: 518044-32-1
Cat No.: BADC-01130
Purity: ≥95%
4.5 
Hydroxy-PEG4-t-butyl ester is a protected PEG linker intermediate used in ADC synthesis. The t-butyl group protects the acid functionality, enabling selective conjugation steps while the PEG4 spacer enhances biocompatibility and payload solubility.
Structure of 518044-32-1
* For research and manufacturing use only. We do not sell to patients.
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | $-- | In stock |
Looking for different specifications? Click to request a custom quote!
Capabilities & Facilities
Popular Publications Citing BOC Sciences Products
Hydroxy-PEG4-t-butyl ester, a polyethylene glycol (PEG) derivative widely employed in diverse biochemical and pharmaceutical realms:
Drug Delivery Systems: In drug modification, Hydroxy-PEG4-t-butyl ester is utilized to enhance the solubility, stability, and bioavailability of therapeutic compounds. By covalently bonding PEG moieties to drugs, it elongates their circulation period and mitigates immunogenic responses, ultimately amplifying the efficacy of treatment regimens.
Surface Modification: Hydroxy-PEG4-t-butyl ester plays a pivotal role in the surface functionalization of nanoparticles, implants, and biosensors. Through the process of PEGylation, a hydrophilic shield is erected, thwarting protein adhesion and biofouling, thereby enhancing the biocompatibility and functionality of these critical medical tools.
Protein Conjugation: In protein engineering, Hydroxy-PEG4-t-butyl ester facilitates the conjugation of proteins and peptides, elevating their pharmacokinetic profiles. By PEGylating proteins, their vulnerability to degradation by proteases is diminished alongside a reduction in renal clearance, resulting in prolonged systemic activity. This technique underpins the development of biopharmaceutical marvels such as PEGylated interferons and growth factors.
Research Reagents: As a linchpin in the realms of chemical biology and bioconjugation, Hydroxy-PEG4-t-butyl ester stands as a versatile linker and crosslinker. Enabling the attachment of biomolecules like enzymes and antibodies to various substrates without compromising their activity, this compound facilitates the creation of intricate molecular assemblies and functional assays in the laboratory setting.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00926 | Hydroxy-PEG2-t-butyl ester | 133803-81-3 | |
| BADC-01015 | Hydroxy-PEG3-t-butyl ester | 186020-66-6 | |
| BADC-01684 | Hydroxy-PEG3-DBCO | 2566404-76-8 | |
| BADC-01137 | Hydroxy-PEG3-SS-PEG3-alcohol | 5662-81-7 | |
| BADC-01158 | Hydroxy-PEG10-t-butyl ester | 778596-26-2 | |
| BADC-01187 | Hydroxy-PEG1-acid | 89211-34-7 | |
| BADC-01194 | Hydroxy-PEG4-propionic acid | 937188-59-5 |
What role does Hydroxy-PEG4-t-butyl ester play in ADC linkers?
Hydroxy-PEG4-t-butyl ester is used as a protective PEGylated linker intermediate in ADC synthesis. The t-butyl ester protects the carboxyl group during conjugation steps, while the PEG4 spacer improves solubility and reduces steric hindrance during payload attachment.
22/12/2021
Could you explain how Hydroxy-PEG4-t-butyl ester is deprotected for ADC conjugation?
The t-butyl ester can be removed under acidic conditions to expose the free carboxyl group, enabling subsequent coupling to amino-functionalized payloads or antibodies without affecting the PEG4 spacer or overall linker structure.
2/7/2019
We would like to know whether Hydroxy-PEG4-t-butyl ester influences ADC pharmacokinetics.
The PEG4 spacer in Hydroxy-PEG4-t-butyl ester increases hydrophilicity and reduces aggregation, which can improve solubility and circulation time of the final ADC, contributing to favorable pharmacokinetic profiles.
23/12/2016
Good afternoon! Could you kindly share the methods that ensure Hydroxy-PEG4-t-butyl ester quality before conjugation?
Quality control involves HPLC for purity, NMR spectroscopy for structural confirmation, and mass spectrometry for molecular weight verification, ensuring consistent performance in downstream ADC synthesis.
8/4/2019
Good morning! What quality control tests are provided for Hydroxy-PEG4-t-butyl ester?
Hydroxy-PEG4-t-butyl ester is supplied with NMR spectra, mass spectrometry, and a Certificate of Analysis. These documents confirm chemical identity and structural integrity, supporting reproducibility in research applications. Complete analytical reports are included in the supporting materials.
25/3/2016
— Dr. Michael Scott, Senior Chemist (USA)
Hydroxy-PEG4-t-butyl ester provided excellent solubility and reliable conjugation efficiency in our ADC linker projects.
23/12/2016
— Ms. Emily Fischer, Biochemist (Germany)
Batch-to-batch consistency was impressive, facilitating reproducible linker synthesis.
25/3/2016
— Dr. Thomas White, ADC Scientist (UK)
We achieved high yields and minimal side products using Hydroxy-PEG4-t-butyl ester.
8/4/2019
— Dr. Isabelle Laurent, Medicinal Chemist (France)
The reagent integrated seamlessly into multi-step workflows for complex linker designs.
22/12/2021
— Dr. Helena Meyer, Research Scientist (Germany)
Hydroxy-PEG4-t-butyl ester enabled the development of novel PEGylated ADC constructs.
— Prof. Oliver Smith, Medicinal Chemist (UK)
Hydroxy-PEG4-t-butyl ester provided by BOC Sciences performed excellently in our linker synthesis. The product’s stability and batch consistency were impressive.
2/7/2019
Hydroxy-PEG4-t-butyl ester
Required fields are marked with *
Hydroxy-PEG4-t-butyl ester
Required fields are marked with *
Contact our experts today for pricing and comprehensive details on our ADC offerings.
From cytotoxin synthesis to linker design, discover our specialized services that complement your ADC projects.
Learn more about payload design, linker strategies, and integrated CDMO support through our curated ADC content.
Find exactly what your project needs from our expanded range of ADCs, offering flexible options to fit your timelines and goals.
