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Hydroxy-PEG10-Boc is extacted from patent CN108707228 (example 0024). Hydroxy-PEG10-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG10-Boc can be conjugated to Paclitaxel (HY-B0015) or docetaxel (HY-B0011).
| Catalog Number | Size | Price | Quantity | |
|---|---|---|---|---|
| BADC-01158 | -- | $-- | Inquiry |
Hydroxy-PEG10-t-butyl ester, a versatile compound highly prevalent in biochemical and pharmaceutical spheres, boasts an array of applications. Here are four key applications of Hydroxy-PEG10-t-butyl ester:
Pharmaceutical Formulations: Embedded within drug delivery systems, Hydroxy-PEG10-t-butyl ester plays a pivotal role in enhancing the solubility and stability of pharmaceutical compounds. By conjugating this compound with therapeutic agents, drugs can attain superior bioavailability and controlled release profiles, thereby elevating therapeutic efficacy while minimizing adverse effects.
Protein and Peptide Conjugation: Employed in the alteration of proteins and peptides, Hydroxy-PEG10-t-butyl ester serves to augment their pharmacokinetic properties. Through the attachment of this compound, the modified biomolecules exhibit heightened solubility, diminished immunogenicity, and prolonged circulation time, culminating in an enhanced therapeutic potential for biologics.
Surface Modification: In the realm of surface modification, Hydroxy-PEG10-t-butyl ester finds utility in enhancing the hydrophilicity of nanoparticles, medical devices, and biomaterials, effectively mitigating non-specific protein binding. This technique is instrumental in the development of biocompatible materials for medical implants, drug delivery carriers, and diagnostic devices, fostering enhanced biocompatibility and reduced fouling for superior performance in biomedical applications.
Diagnostic Imaging: Within the domain of diagnostic imaging, Hydroxy-PEG10-t-butyl ester can be harnessed to functionalize imaging agents, including contrast agents for MRI or fluorescent probes. By augmenting the solubility and stability of these agents, the compound amplifies their imaging capabilities, resulting in heightened diagnostic accuracy and intricate visualization of biological tissues and processes.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
