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CAS No.: 89211-34-7
Cat No.: BADC-01187
Purity: ≥95%
4.5 
Hydroxy-PEG1-acid is a hydrophilic ADC linker intermediate with a short PEG1 spacer and terminal carboxyl group, enhancing solubility and enabling versatile conjugation in antibody-drug conjugates for improved payload stability and delivery. Keywords: ADC linker, PEG linker, hydrophilic spacer, payload conjugation, antibody-drug conjugate.
Structure of 89211-34-7
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Hydroxy-PEG1-acid, a versatile compound highly valued in the bioscience industry for its exceptional properties, finds wide-ranging applications. Here are key applications of Hydroxy-PEG1-acid:
Drug Delivery: Harnessing the power of Hydroxy-PEG1-acid, researchers delve into enhancing the pharmacokinetics and stability of therapeutic agents. Through the strategic conjugation of drugs with PEG1-acid, solubility is amplified, and immunogenicity is curtailed, culminating in heightened bioavailability and prolonged circulation within the bloodstream.
Bioconjugation: In the intricate realm of protein and peptide chemistry, Hydroxy-PEG1-acid takes center stage in the process of PEGylation, wherein biomolecules undergo a metamorphosis. By affixing PEG chains to proteins or peptides, stability is bolstered, proteolytic degradation is subdued, and immunogenicity takes a back seat.
Biomolecular Probes: Delving into the realm of diagnostics and imaging, Hydroxy-PEG1-acid assumes a crucial role as a linker in the synthesis of biomolecular probes. These probes are meticulously crafted to hone in on specific biomarkers or cells, facilitating their discernment in diverse assays and imaging modalities. The innate flexibility and hydrophilicity endowed by PEG1-acid serve to elevate probe performance and precision, setting new benchmarks in probe technology.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00926 | Hydroxy-PEG2-t-butyl ester | 133803-81-3 | |
| BADC-01015 | Hydroxy-PEG3-t-butyl ester | 186020-66-6 | |
| BADC-01684 | Hydroxy-PEG3-DBCO | 2566404-76-8 | |
| BADC-01130 | Hydroxy-PEG4-t-butyl ester | 518044-32-1 | |
| BADC-01137 | Hydroxy-PEG3-SS-PEG3-alcohol | 5662-81-7 | |
| BADC-01158 | Hydroxy-PEG10-t-butyl ester | 778596-26-2 | |
| BADC-01194 | Hydroxy-PEG4-propionic acid | 937188-59-5 |
Hydroxy-PEG1-acid
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Hydroxy-PEG1-acid
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