Hydroxy-PEG1-acid - CAS 89211-34-7

Hydroxy-PEG1-acid - CAS 89211-34-7 Catalog number: BADC-01187

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Hydroxy-PEG1-acid is a non-cleavable 1-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).

Category
ADCs Linker
Product Name
Hydroxy-PEG1-acid
CAS
89211-34-7
Catalog Number
BADC-01187
Molecular Formula
C5H10O4
Molecular Weight
134.13
Purity
≥95%
Hydroxy-PEG1-acid

Ordering Information

Catalog Number Size Price Quantity
BADC-01187 -- $-- Inquiry
Description
Hydroxy-PEG1-acid is a non-cleavable 1-unit PEG linker that can be used to synthesize antibody-conjugated drugs (ADCs).
Synonyms
OH-PEG1-COOH; HO-PEG1-Propionic acid; HO-PEG1-CH2CH2COOH; Hydroxy-PEG1-propionic acid; 3-(2-hydroxyethoxy)propionic acid; Propanoic acid, 3-(2-hydroxyethoxy)-
IUPAC Name
3-(2-hydroxyethoxy)propanoic acid
Canonical SMILES
C(COCCO)C(=O)O
InChI
InChI=1S/C5H10O4/c6-2-4-9-3-1-5(7)8/h6H,1-4H2,(H,7,8)
InChIKey
GTIFLSYPOXYYFG-UHFFFAOYSA-N
Density
1.224±0.06 g/cm3 (Predicted)
Solubility
Soluble in DMSO
PSA
66.76000
Appearance
Pale Yellow or Colorless Oily Matter
Shelf Life
0-4°C for short term (days to weeks), or -20°C for long term (months).
Shipping
-20°C (International: -20°C)
Storage
Store at 2-8°C
Boiling Point
127-130°C at 2 Torr
Form
Solid

Hydroxy-PEG1-acid, a versatile compound highly valued in the bioscience industry for its exceptional properties, finds wide-ranging applications. Here are key applications of Hydroxy-PEG1-acid:

Drug Delivery: Harnessing the power of Hydroxy-PEG1-acid, researchers delve into enhancing the pharmacokinetics and stability of therapeutic agents. Through the strategic conjugation of drugs with PEG1-acid, solubility is amplified, and immunogenicity is curtailed, culminating in heightened bioavailability and prolonged circulation within the bloodstream.

Bioconjugation: In the intricate realm of protein and peptide chemistry, Hydroxy-PEG1-acid takes center stage in the process of PEGylation, wherein biomolecules undergo a metamorphosis. By affixing PEG chains to proteins or peptides, stability is bolstered, proteolytic degradation is subdued, and immunogenicity takes a back seat.

Biomolecular Probes: Delving into the realm of diagnostics and imaging, Hydroxy-PEG1-acid assumes a crucial role as a linker in the synthesis of biomolecular probes. These probes are meticulously crafted to hone in on specific biomarkers or cells, facilitating their discernment in diverse assays and imaging modalities. The innate flexibility and hydrophilicity endowed by PEG1-acid serve to elevate probe performance and precision, setting new benchmarks in probe technology.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Historical Records: Hydroxy-PEG1-acid
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