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CAS No.: 186020-66-6
Cat No.: BADC-01015
Purity: ≥95%
4.5 
Hydroxy-PEG3-t-butyl ester is a PEG-based spacer and synthetic linker building block used to introduce a defined hydrophilic and flexible segment into multistep conjugation designs. The PEG chain can increase molecular spacing and provide a modular connection between reactive groups without serving as a dedicated cleavage trigger. This derivative contains peg3 spacer together with terminal functionality selected for further synthesis. The available reactive group is no dedicated antibody-reactive group unless activated/functionalized; terminal functionality depends on the specific peg derivative. The opposite terminus provides terminal hydroxyl; requires derivatizatioctivation before payload coupling. Coupling and deprotection conditions should be matched to the terminal groups and the intended order of assembly.
Structure of 186020-66-6
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Hydroxy-PEG3-t-butyl ester, a bifunctional polyethylene glycol derivative, finds diverse applications in both chemical and biological realms. Here are four key applications of Hydroxy-PEG3-t-butyl ester:
Drug Delivery Systems: In drug delivery systems, Hydroxy-PEG3-t-butyl ester facilitates the formulation of pharmaceutical compounds by enhancing their solubility and stability. By conjugating drugs with this PEG derivative, researchers can augment drug bioavailability and prolong circulation time within the body.
Bioconjugation: Serving as a versatile linker molecule for bioconjugation reactions, Hydroxy-PEG3-t-butyl ester enables the coupling of biomolecules like peptides, proteins, and antibodies. This conjugation not only bolsters the stability and solubility of biomolecules but also mitigates immunogenicity concerns.
Surface Modification: By enveloping surfaces with Hydroxy-PEG3-t-butyl ester, researchers can forge antifouling surfaces that hinder protein adsorption and cellular adhesion. This tailored modification proves exceedingly beneficial in the advancement of biosensors and implantable medical technologies.
Polymer Synthesis: Acting as a foundational element in polymer synthesis, Hydroxy-PEG3-t-butyl ester contributes to the creation of block copolymers and cutting-edge polymers. Its inclusion introduces specific functional groups that can be further tailored for diverse chemical applications. This innovative synthesis methodology enables the production of bespoke polymers with desired characteristics, shaping the landscape of materials science and nanotechnology with bespoke solutions.
Hydroxy-PEG3-t-butyl ester
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Hydroxy-PEG3-t-butyl ester
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