Name: Hydroxy-PEG3-t-butyl ester
Brand: BOC Sciences
Price: -- USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

$--

In stock

Synonyms

HO-PEG3-CH2CH2COOtBu; Hydroxy-PEG3-(CH2)2-Boc; OH-PEG3-TBA; OH-PEG3-CH2CH2COOtBu; HO-PEG3-t-butyl ester; tert-Butyl 12-hydroxy-4,7,10-trioxadodecanoate; 3-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester; 12-Hydroxy-4,7,10-trioxadodecanoic Acid tert-Butyl Ester; 2-Methyl-2-propanyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester; tert-Butyl triethylene glycol-O-propionate

IUPAC Name

tert-butyl 3-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]propanoate

Canonical SMILES

CC(C)(C)OC(=O)CCOCCOCCOCCO

InChI

InChI=1S/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3

InChIKey

KSXVEOLRERRELV-UHFFFAOYSA-N

Density

1.052 g/mL at 20°C

Solubility

Soluble in DMSO (10 mm)

Flash Point

125.2°C

Index Of Refraction

1.45

PSA

74.22000

Vapor Pressure

7.78E-07mmHg at 25°C

Appearance

Colorless to light yellow to light orange clear liquid

Shipping

Room temperature, or blue ice upon request.

Storage

Store at 2-8°C

Boiling Point

365.8±27.0°C (Predicted)

Form

Liquid

Biological Activity

Hydroxy-PEG2-(CH2)2-Boc is a uncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Hydroxy-PEG2- (CH2)2-Boc is extracted from patent WO2004008101A2 (compound 196)[1] . In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Hydroxy-PEG3-t-butyl ester, a bifunctional polyethylene glycol derivative, finds diverse applications in both chemical and biological realms. Here are four key applications of Hydroxy-PEG3-t-butyl ester:

Drug Delivery Systems: In drug delivery systems, Hydroxy-PEG3-t-butyl ester facilitates the formulation of pharmaceutical compounds by enhancing their solubility and stability. By conjugating drugs with this PEG derivative, researchers can augment drug bioavailability and prolong circulation time within the body.

Bioconjugation: Serving as a versatile linker molecule for bioconjugation reactions, Hydroxy-PEG3-t-butyl ester enables the coupling of biomolecules like peptides, proteins, and antibodies. This conjugation not only bolsters the stability and solubility of biomolecules but also mitigates immunogenicity concerns.

Surface Modification: By enveloping surfaces with Hydroxy-PEG3-t-butyl ester, researchers can forge antifouling surfaces that hinder protein adsorption and cellular adhesion. This tailored modification proves exceedingly beneficial in the advancement of biosensors and implantable medical technologies.

Polymer Synthesis: Acting as a foundational element in polymer synthesis, Hydroxy-PEG3-t-butyl ester contributes to the creation of block copolymers and cutting-edge polymers. Its inclusion introduces specific functional groups that can be further tailored for diverse chemical applications. This innovative synthesis methodology enables the production of bespoke polymers with desired characteristics, shaping the landscape of materials science and nanotechnology with bespoke solutions.

Catalog	Product Name	CAS
BADC-00926	Hydroxy-PEG2-t-butyl ester	133803-81-3
BADC-01684	Hydroxy-PEG3-DBCO	2566404-76-8
BADC-01130	Hydroxy-PEG4-t-butyl ester	518044-32-1
BADC-01137	Hydroxy-PEG3-SS-PEG3-alcohol	5662-81-7
BADC-01158	Hydroxy-PEG10-t-butyl ester	778596-26-2
BADC-01187	Hydroxy-PEG1-acid	89211-34-7
BADC-01194	Hydroxy-PEG4-propionic acid	937188-59-5