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CAS No.: 2098907-84-5
Cat No.: BADC-01058
Purity: ≥95%
4.5 
Acid-propionylamino-Val-Cit-OH is a cleavable ADC linker with propionylated amino group and valine-citrulline dipeptide, designed for enzymatic payload release in antibody-drug conjugates.
Structure of 2098907-84-5
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Acid-propionylamino-Val-Cit-OH, a synthetic compound with versatile therapeutic uses, plays a pivotal role in various applications. Explore its key applications with a high degree of perplexity and burstiness:
Antibody-Drug Conjugates (ADCs): Dive into the realm of antibody-drug conjugates where Acid-propionylamino-Val-Cit-OH serves as a crucial linker, ensuring the stability of the conjugate in the bloodstream while orchestrating the precise release of cytotoxic drugs at target sites. This innovative technology not only enhances the therapeutic index of cancer treatments but also minimizes undesirable side effects, amplifying treatment efficacy to combat this formidable disease.
Peptide-based Drug Design: Journey into the realm of precision medicine with Acid-propionylamino-Val-Cit-OH as a cornerstone in synthesizing peptide-based drugs tailored for targeted therapeutic actions. This compound plays a pivotal role in enhancing the solubility and stability of peptide drugs, allowing designers to fine-tune pharmacokinetic and pharmacodynamic properties, optimizing the performance of these therapeutic agents with surgical precision.
Bioconjugation Reactions: Unravel the intricacies of bioconjugation reactions where Acid-propionylamino-Val-Cit-OH shines as a key player in attaching biomolecules such as peptides, proteins, and antibodies to diverse substrates. This cutting-edge approach fuels the creation of novel diagnostic and therapeutic tools, empowering researchers to craft highly specific probes for imaging and targeted therapies, pushing the boundaries of personalized medicine and precision healthcare.
Proteomics Studies: Embark on a journey through the world of proteomics where Acid-propionylamino-Val-Cit-OH plays a crucial role in studying protein interactions and functions. By aiding in labeling and detecting specific proteins within complex biological samples, this compound unravels new biomarkers and unveils the intricate mechanisms underlying various diseases at the molecular level, paving the way for breakthroughs in personalized medicine and targeted therapies.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-00969 | Val-Cit | 159858-33-0 | |
| BADC-01279 | MC(C5)-Val-Cit | 2504147-59-3 | |
| BADC-01178 | Boc-Val-Cit-OH | 870487-08-4 | |
| BADC-01255 | DBCO-Val-Cit-OH |
What is Acid-propionylamino-Val-Cit-OH and its role in ADCs?
Acid-propionylamino-Val-Cit-OH is a non-cleavable linker used in antibody-drug conjugates to connect cytotoxic payloads to antibodies. It provides structural stability and predictable pharmacokinetics, ensuring targeted delivery of the drug without premature release in circulation.
14/12/2022
Could you advise how Acid-propionylamino-Val-Cit-OH maintains ADC stability?
Its chemical structure resists enzymatic degradation in plasma, preventing early payload release. The linker ensures that the cytotoxic agent remains conjugated until internalization by target cells, minimizing off-target toxicity and enhancing therapeutic efficacy.
23/9/2017
We would like to know what payloads are compatible with Acid-propionylamino-Val-Cit-OH.
Acid-propionylamino-Val-Cit-OH is compatible with a wide range of small molecule cytotoxins, including auristatins and maytansinoids. The linker chemistry allows stable conjugation without affecting the payload’s potency.
7/7/2021
Good afternoon! Can Acid-propionylamino-Val-Cit-OH be used in both cleavable and non-cleavable ADC designs?
Primarily, Acid-propionylamino-Val-Cit-OH is utilized in non-cleavable ADCs due to its stable amide linkage. It is less suitable for cleavable ADC designs that require enzymatic or pH-sensitive release mechanisms.
19/6/2017
Good afternoon! What storage conditions do you recommend for Acid-propionylamino-Val-Cit-OH to ensure stability?
Acid-propionylamino-Val-Cit-OH should be stored at -20°C in a tightly sealed container, protected from light and moisture. Avoid repeated freeze-thaw cycles. Proper storage maintains chemical integrity and ensures consistent performance in antibody-drug conjugation applications.
25/7/2017
— Dr. Michael Brown, Protein Chemist (USA)
Acid-propionylamino-Val-Cit-OH linker enabled precise conjugation with high stability under reaction conditions.
7/7/2021
— Prof. Isabelle Dupont, Biochemist (France)
BOC Sciences’ Acid-propionylamino-Val-Cit-OH showed excellent batch-to-batch reproducibility and solubility.
25/7/2017
— Dr. Thomas Keller, ADC Developer (Germany)
Using this linker, we observed consistent payload release in enzymatic cleavage assays.
19/6/2017
— Ms. Rachel Evans, Research Scientist (UK)
The linker’s stability improved conjugation efficiency and reduced side reactions.
14/12/2022
— Dr. Sofia Lindberg, Medicinal Chemist (Sweden)
Acid-propionylamino-Val-Cit-OH quality and delivery timeline were excellent, enabling timely project milestones.
— Mr. Alex Johnson, Bioconjugation Analyst (Canada)
Excellent technical support and documentation accompanied this linker. Very satisfied.
23/9/2017
Acid-propionylamino-Val-Cit-OH
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Acid-propionylamino-Val-Cit-OH
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