Seco-Duocarmycin MA - CAS 1613286-57-9
  1. Home
  2. Products
  3. ADCs Cytotoxin
  4. Duocarmycins
  5. Seco-Duocarmycin MA

Seco-Duocarmycin MA - CAS 1613286-57-9 Catalog number: BADC-00342

* Please be kindly noted products are not for therapeutic use. We do not sell to patients.

Seco-Duocarmycin MA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.

Category
ADCs Cytotoxin
Product Name
Seco-Duocarmycin MA
CAS
1613286-57-9
Catalog Number
BADC-00342
Molecular Formula
C34H31ClN4O5
Molecular Weight
611.09
Purity
≥95%
Target
DNA
Seco-Duocarmycin MA

Ordering Information

Catalog Number Size Price Quantity
BADC-00342 -- $-- Inquiry

Featured Recommendations

Recommended Services
ADC Linkers Development Antibody Modification and Conjugation Technologies ADC Analysis and Characterization ADC Linker and Cytotoxin Conjugations ADC Payloads Development ADC Manufacture ADC Development for Targets ADC Development Platform
Other Types of Cytotoxins
Auristatins Calicheamicins Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Piericidins Pyrrolobenzodiazepines Traditional Cytotoxic Agents Others
Description
Seco-Duocarmycin MA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Synonyms
Carbamic acid, N-​[4-​[[[2-​[[(1S)​-​1-​(chloromethyl)​-​1,​2-​dihydro-​5-​hydroxy-​3H-​benz[e]​indol-​3-​yl]​carbonyl]​-​1H-​indol-​6-​yl]​amino]​carbonyl]​phenyl]​-​, 1,​1-​dimethylethyl ester;
IUPAC Name
tert-butyl N-[4-[[2-[(1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydrobenzo[e]indole-3-carbonyl]-1H-indol-6-yl]carbamoyl]phenyl]carbamate
Canonical SMILES
CC(C)(C)OC(=O)NC1=CC=C(C=C1)C(=O)NC2=CC3=C(C=C2)C=C(N3)C(=O)N4CC(C5=C4C=C(C6=CC=CC=C65)O)CCl
InChI
InChI=1S/C34H31ClN4O5/c1-34(2,3)44-33(43)37-22-11-8-19(9-12-22)31(41)36-23-13-10-20-14-27(38-26(20)15-23)32(42)39-18-21(17-35)30-25-7-5-4-6-24(25)29(40)16-28(30)39/h4-16,21,38,40H,17-18H2,1-3H3,(H,36,41)(H,37,43)/t21-/m1/s1
InChIKey
MZXQBIDDBQCHFP-OAQYLSRUSA-N
Appearance
Soild powder
Shipping
Room temperature, or blue ice upon request.
1. Structural necessity of indole C5-O-substitution of seco-duocarmycin analogs for their cytotoxic activity
Eunsook Ma, Taeyoung Choi Molecules . 2010 Nov 8;15(11):7971-84. doi: 10.3390/molecules15117971.
A series of racemic indole C5-O-substituted seco-cyclopropylindole (seco-CI) compounds 1-5 were prepared by coupling in the presence of EDCI of 1-(tert-butyloxycarbonyl)-3-(chloromethyl)indoline (seg-A) with 5-hydroxy-, 5-O-methylsulfonyl, 5-O-aminosulfonyl, 5-O-(N,N-dimethylaminosulfonyl)- and 5-O-benzyl-1H-indole-2-carboxylic acid as seg-B. Compounds 1-5 were tested for cytotoxic activity against four human cancer cell lines (COLO 205, SK-MEL-2, A549, and JEG-3) using a MTT assay. Compounds 2 and 3 with small sized sulfonyl substituents like 5-O-methylsulfonyl and 5-O-aminosulfonyl exhibit a similar level of activity as doxorubicin against all cell lines tested.
2. Structural influence of indole C5-N-substitutents on the cytotoxicity of seco-duocarmycin analogs
Eunsook Ma, Taeyoung Choi Arch Pharm Res . 2011 Mar;34(3):357-67. doi: 10.1007/s12272-011-0302-1.
A series of racemic indole C5-substituted seco-cyclopropylindoline compounds (2,3 and 5-7) were prepared by coupling 1-(tert-butyloxycarbonyl)-3-(chlorocarbonyl)indoline (seg-A) with 5,6,7-trimethoxy-, 5,6-dimethoxy-, 5-amino-, 5-methylsulfonylamino- and 5-(N,N-dimethylaminosulfonylamino) indole-2-carboxylic acid as seg-B in the presence of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide. The synthetic compounds (2,3 and 5-7) were tested for cytotoxic activity against human cancer cell lines (COLO 205, SK-MEL-2, A549, and JEG-3) using the MTT assay.
The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Calculate
The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Calculate

Related Products

Doxorubicin EP Impurity A (Daunorubicin)
Doxorubicin EP Impurity A (Daunorubicin)
(CAS: 20830-81-3)
Mytoxin B
Mytoxin B
(CAS: 105049-15-8)
Paclitaxel
Paclitaxel
(CAS: 33069-62-4)
MMAE
MMAE
(CAS: 474645-27-7)
Vipivotide tetraxetan
Vipivotide tetraxetan
(CAS: 1702967-37-0)
Doxorubicin hydrochloride
Doxorubicin hydrochloride
(CAS: 25316-40-9)
Historical Records: Seco-Duocarmycin MA
Why Choose BOC Sciences?

Customer Support

Providing excellent 24/7 customer service and support

Project Management

Offering 100% high-quality services at all stages

Quality Assurance

Ensuring the quality and reliability of products or services

Global Delivery

Ensuring timely delivery of products worldwide

Featured Services
cGMP Grade Products

BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
Site-Specific Conjugation

BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
Linkers for Bioconjugation

BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
ADC Targets
Questions & Comments
Verification code
Send Inquiry
Verification code
Resources & Supports
Inquiry Basket
loading Loading ......
Delete selectedGo to checkout