Name: Bis(NHS)PEG5
Brand: BOC Sciences
Price: -- USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

$--

In stock

Synonyms

Bis-PEG5-NHS ester; Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16-pentaoxanonadecane-1,19-dioate; NHS-PEG5-NHS; Bis-dPEG(R)5-NHS ester; Bis(2,5-dioxopyrrolidin-1-yl) 4,7,10,13,16-pentaoxanonadecanedioate; Bis(3-PEG4)propionic acid N-hydroxysuccinimide diester; 1,1'-[(1,19-Dioxo-4,7,10,13,16-pentaoxanonadecane-1,19-diyl)bis(oxy)]di(2,5-pyrrolidinedione); 2,5-Pyrrolidinedione, 1,1'-[(1,19-dioxo-4,7,10,13,16-pentaoxanonadecane-1,19-diyl)bis(oxy)]bis-; α,ω-disuccinimidyl tetraethylene glycol

IUPAC Name

(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate

Canonical SMILES

C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCC(=O)ON2C(=O)CCC2=O

InChI

InChI=1S/C22H32N2O13/c25-17-1-2-18(26)23(17)36-21(29)5-7-31-9-11-33-13-15-35-16-14-34-12-10-32-8-6-22(30)37-24-19(27)3-4-20(24)28/h1-16H2

InChIKey

FTYUGLBWKRXQBD-UHFFFAOYSA-N

Density

1.4±0.1 g/cm3

Solubility

Soluble in DCM, DMF, DMSO

PSA

173.51000

Appearance

Colorless to Yellow Clear Liquid to Cloudy Liquid

Shipping

Room temperature

Storage

Store at 2-8°C

Boiling Point

632.5±65.0°C at 760 mmHg

Bis(NHS)PEG5, a versatile bifunctional polyethylene glycol (PEG) crosslinker, finds wide-ranging applications in bioconjugation and chemical biology. Here are four key applications of Bis(NHS)PEG5:

Protein-Protein Conjugation: This intricate process involves utilizing Bis(NHS)PEG5 to facilitate the conjugation of two proteins, forming stable amide bonds between their amino groups. Particularly crucial in creating antibody-drug conjugates for targeted cancer therapies, this crosslinker’s PEG spacer enhances solubility and reduces steric hindrance, optimizing the bioactivity of the resulting complex.

Surface Functionalization: Researchers leverage the power of Bis(NHS)PEG5 to modify surfaces of nanoparticles, biomaterials, and biosensors. By attaching Bis(NHS)PEG5, specific functional groups are introduced that enable the binding of molecules like antibodies or enzymes on diverse surfaces. This precision is pivotal in developing diagnostic devices and bioanalytical tools, ensuring high specificity and sensitivity in molecular interactions.

Drug Delivery Systems: Bis(NHS)PEG5 plays a pivotal role in creating polymer-based drug delivery systems with controlled release capabilities. Through PEGylation of drug carriers, such as liposomes or nanoparticles, using Bis(NHS)PEG5, stability and circulation time in the bloodstream are enhanced. This strategic approach enables more efficient drug targeting, reduces immunogenicity, and ultimately yields superior therapeutic outcomes for patients.

Tissue Engineering: In the domain of tissue engineering, Bis(NHS)PEG5 serves as a vital tool for crosslinking hydrogels and scaffolds, enhancing their mechanical strength and biocompatibility. By skillfully linking natural or synthetic polymers using Bis(NHS)PEG5, researchers create three-dimensional structures closely mimicking the extracellular matrix. This advancement supports crucial processes like cell attachment, proliferation, and differentiation, propelling tissue-engineered constructs forward in regenerative medicine.