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Hemiasterlin

  CAS No.: 157207-90-4   Cat No.: BADC-01369   Purity: 98% 4.5  

Hemiasterlin, a highly cytotoxic marine natural product, is used in a targeted therapeutic which was demonstrated by incorporation as a payload in an antibody-drug conjugate (ADC). It acts by inducing mitotic arrest and abnormal spindle formation.

Hemiasterlin

Structure of 157207-90-4

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Category
ADC Cytotoxin
Molecular Formula
C30H46N4O4
Molecular Weight
526.71
Shipping
Store at 0-4°C for short term (days to weeks) or -20°C for long term (months to years)

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products
Synonyms
(-)-Hemiasterlin; Milnamide B; (S,E)-2,5-dimethyl-4-((S)-N,3,3-trimethyl-2-((S)-3-methyl-3-(1-methyl-1H-indol-3-yl)-2-(methylamino)butanamido)butanamido)hex-2-enoic acid
IUPAC Name
(E,4S)-4-[[(2S)-3,3-dimethyl-2-[[(2S)-3-methyl-2-(methylamino)-3-(1-methylindol-3-yl)butanoyl]amino]butanoyl]-methylamino]-2,5-dimethylhex-2-enoic acid
Canonical SMILES
CC(C)C(C=C(C)C(=O)O)N(C)C(=O)C(C(C)(C)C)NC(=O)C(C(C)(C)C1=CN(C2=CC=CC=C21)C)NC
InChI
InChI=1S/C30H46N4O4/c1-18(2)23(16-19(3)28(37)38)34(11)27(36)25(29(4,5)6)32-26(35)24(31-9)30(7,8)21-17-33(10)22-15-13-12-14-20(21)22/h12-18,23-25,31H,1-11H3,(H,32,35)(H,37,38)/b19-16+/t23-,24-,25-/m1/s1
InChIKey
KQODQNJLJQHFQV-MKWZWQCGSA-N
Density
1.1±0.1 g/cm3
Solubility
Soluble in DMSO
Storage
Store at 0-4°C for short term (days to weeks) or -20°C for long term (months to years)
Boiling Point
734.2±60.0 °C at 760 mmHg

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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