CAS No.: 175724-30-8
Purity: >98.0%
HNMR
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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(t-butoxycarbonylethoxymethyl)-methane is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
![Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine](https://resource.bocsci.com/structure/175724-30-8.gif)
Structure of 175724-30-8
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| Size | Price | Stock | Quantity |
|---|---|---|---|
| 5 g | $1573 | In stock |
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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a multifunctional ADC linker widely utilized in antibody-drug conjugate development. Its structure features three tert-butoxycarbonyl (Boc)-protected ethoxy groups connected to a central amine, providing multiple sites for controlled payload attachment. In ADC linker design, this architecture allows for the precise conjugation of ADC cytotoxins while maintaining chemical stability under physiological conditions, supporting efficient and reproducible bioconjugation strategies.
The Boc-protected functional groups facilitate selective deprotection and subsequent coupling reactions, enabling attachment of diverse ADC payloads, including microtubule inhibitors, DNA-damaging agents, and other potent cytotoxins. The tris-functional design introduces a degree of spatial separation between conjugated payloads, reducing steric interference with antibody-antigen interactions and enhancing the solubility and overall stability of the resulting ADC.
In ADC payload applications, Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine supports site-specific conjugation and controlled drug-to-antibody ratios (DAR), which are critical for optimizing pharmacokinetics and therapeutic efficacy. Its structural flexibility allows researchers to design complex ADC architectures, including multi-payload conjugates, while maintaining antibody functionality and reducing aggregation tendencies.
This ADC linker is widely applied in oncology-focused bioconjugation workflows, where chemical robustness, linker versatility, and controlled reactivity are essential. The combination of Boc protection, tris-functional architecture, and hydrophilic ethoxy spacers provides a reliable platform for constructing high-performance antibody-drug conjugates with reproducible linker stability, efficient payload delivery, and optimized therapeutic potential.
What is Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine?
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine is a multifunctional linker widely used in ADC construction. It provides steric protection and enhanced solubility while offering functional groups suitable for conjugation to antibodies and cytotoxic payloads in targeted drug delivery applications.
7/7/2019
We are interested in how Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine improves ADC stability.
The structural design of Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine reduces steric hindrance and prevents premature cleavage. Its chemical stability under physiological conditions ensures controlled release of the payload, which is critical for maintaining ADC efficacy and minimizing off-target toxicity.
5/9/2019
Could you provide the recommended storage conditions for Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine?
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine should be stored at low temperatures, typically -20°C, in a dry and inert atmosphere to prevent moisture-induced hydrolysis and maintain its structural integrity over extended periods.
19/2/2019
Dear Sir, may I ask if certificates of analysis are available for Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine?
Yes, BOC Sciences provides comprehensive documentation including certificates of analysis (CoA) that cover identity, structural verification, and analytical characterization to support regulatory submissions and quality control processes.
28/6/2020
Dear team, what analytical methods are recommended for Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine?
Analytical verification can be performed using NMR spectroscopy, LC-MS, and HPLC techniques. These methods ensure structural integrity and functional group availability for subsequent conjugation reactions.
9/8/2021
— Dr. Jonathan White, Medicinal Chemist (UK)
This complex linker performed exceptionally well in our ADC synthesis. Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine maintained integrity under challenging reaction conditions.
19/2/2019
— Ms. Clara Hoffmann, Biochemist (Germany)
BOC Sciences provided Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine with detailed QC, ensuring reproducible results in our multi-step synthesis.
9/8/2021
— Dr. William Parker, Senior Scientist (USA)
Excellent solubility and stability of this linker facilitated efficient conjugation and minimized side reactions.
28/6/2020
— Dr. Elise Moreau, Chemist (France)
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine allowed high-yield synthesis of our ADC intermediates, saving time and resources.
7/7/2019
— Mr. Noah Brown, Bioconjugation Specialist (Canada)
The technical team assisted us in optimizing Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine usage, enhancing reproducibility.
— Dr. Isabella Taylor, Senior Researcher (USA)
High-quality product with consistent lot-to-lot performance enabled smooth workflow in our ADC pipeline.
5/9/2019
Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
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Tris[[2-(tert-butoxycarbonyl)ethoxy]methyl]methylamine
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