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CAS No.:
Cat No.: BADC-01217
Purity: ≥95%
4.5 
APN-PEG4-BCN is a bioorthogonal ADC linker combining PEG4 spacer and BCN for click chemistry. It enhances antibody conjugation efficiency and payload stability in ADCs for targeted drug delivery in oncology research.
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APN-PEG4-BCN, a versatile bifunctional linker utilized in the realms of chemical biology and bioconjugation, finds wide-ranging applications across various domains. Here are four key applications of APN-PEG4-BCN:
Protein Labeling: A common practice in research, the utilization of APN-PEG4-BCN in protein labeling serves as a pivotal tool for attaching tags or probes to specific proteins. The BCN (bicyclo[6.1.0]nonyne) moiety partakes in a copper-free click reaction with azide-functionalized molecules, ensuring precise and enduring attachment. This methodology empowers researchers to monitor proteins within intricate cellular environments and investigate protein-protein interactions with meticulous detail.
Drug Delivery: Embarking on a journey toward advanced drug delivery systems, the conjugation of therapeutic agents to biocompatible carriers using APN-PEG4-BCN opens new horizons. The inclusion of the PEG (polyethylene glycol) component augments solubility and diminishes immunogenicity, thereby elevating drug efficacy and stability. By linking drugs to specifically tailored carriers, targeted delivery to precise tissues or cells is achieved, leading to a substantial reduction in undesirable side effects while maximizing therapeutic impact.
Diagnostic Imaging: In the realm of diagnostic imaging, APN-PEG4-BCN emerges as a valuable asset in the creation of imaging agents crucial for visualizing biological processes in vivo. By coupling imaging probes like fluorescent dyes or radioisotopes to peptides or antibodies, this compound plays a pivotal role in disease diagnosis, monitoring therapeutic responses, and guiding intricate surgical procedures. Its contribution to enhancing imaging precision and efficacy is instrumental in the evolution of medical diagnostics.
Biomaterials Development: The application of APN-PEG4-BCN in biomaterials modification signifies a significant stride toward enhancing material functionality. By tethering this compound to surfaces of medical implants or scaffolds, biocompatibility and cellular adhesion are promoted, rendering the materials more suitable for applications in tissue engineering and regenerative medicine. This transformative approach holds the potential to revolutionize the field of biomaterials, creating opportunities for innovative solutions in healthcare and beyond.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01216 | APN-PEG4-Amine hydrochloride | ||
| BADC-01218 | APN-PEG4-DBCO | ||
| BADC-01219 | APN-PEG4-tetrazine | ||
| BADC-01871 | APN-PEG36-tetrazine |
APN-PEG4-BCN
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APN-PEG4-BCN
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