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CAS No.:
Cat No.: BADC-01218
Purity: ≥95%
4.5 
APN-PEG4-DBCO is a cleavable ADC linker featuring PEG4 and DBCO for efficient strain-promoted click conjugation. It supports stable payload attachment and controlled release in antibody-drug conjugates for cancer therapeutics.
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APN-PEG4-DBCO, a versatile chemical linker prevalent in bioconjugation applications, finds its niche in proteomics, drug delivery, and molecular biology.
Antibody-Drug Conjugates (ADCs): Within the realm of oncology, APN-PEG4-DBCO plays a pivotal role in linking potent cytotoxic agents to antibodies designed to seek out and destroy cancerous cells. This targeted approach not only boosts drug efficacy but also minimizes collateral damage to healthy tissues. By utilizing APN-PEG4-DBCO, researchers ensure the stable and effective conjugation of therapeutic payloads with precision and finesse.
Protein Labeling: Delving into the intricate world of protein research, scientists turn to APN-PEG4-DBCO for the site-specific labeling of proteins with fluorescent dyes and molecular tags. This meticulous tagging allows for the visual tracking of proteins during cellular processes, enhancing our understanding of biological mechanisms. The reliability and specificity enabled by APN-PEG4-DBCO are paramount for ensuring the accuracy and reproducibility of experimental findings.
Click Chemistry Reactions: At the forefront of molecular engineering, APN-PEG4-DBCO serves as a linchpin in bioorthogonal click chemistry, facilitating the covalent attachment of biomolecules under physiological conditions. Coupled with azide-functionalized compounds, this compound enables rapid and selective bioconjugation, revolutionizing fields like protein manipulation, drug synthesis, and diagnostics. The versatility of click chemistry underpins advancements in various scientific disciplines.
Nanoparticle Functionalization: Driving innovation in targeted drug delivery systems, APN-PEG4-DBCO emerges as a crucial element in attaching targeting ligands and therapeutic payloads to nanoparticles. This strategic conjugation ensures precise delivery of medications to diseased cells or tissues, heralding a paradigm shift in treatment efficacy. With the PEG4 spacer enhancing biocompatibility and mitigating immunogenic responses, APN-PEG4-DBCO stands as a cornerstone in the evolution of nanoparticle technology.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01216 | APN-PEG4-Amine hydrochloride | ||
| BADC-01217 | APN-PEG4-BCN | ||
| BADC-01219 | APN-PEG4-tetrazine | ||
| BADC-01871 | APN-PEG36-tetrazine |
APN-PEG4-DBCO
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APN-PEG4-DBCO
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