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Dov-Val-Dil-OH is an intermediate of dolastoxin, a cytotoxic liner peptide produced by Dolabbella auriclaria which exhibits potent antitumor activity.
| Catalog Number | Size | Price | Quantity | ||
|---|---|---|---|---|---|
| BADC-01575 | -- | $-- | Inquiry |
Dov-Val-Dil-OH, a fascinating molecule in the realm of medicinal chemistry, is pivotal as an intermediate for the synthesis of dolastoxin. Dolastoxin, a cytotoxic linear peptide, is sourced from the sea hare species Dolabella auricularia, known for its potent antitumor properties. The appeal of Dov-Val-Dil-OH lies not only in its structural complexity but also in its therapeutic potential to contribute significantly to cancer treatment.
The role of Dov-Val-Dil-OH in drug discovery is underscored by its versatility in organic synthesis processes, where precision and control are paramount. It acts as an integral building block in creating larger, biologically active molecules such as dolastoxin. By participating in reactions that form peptide bonds, Dov-Val-Dil-OH contributes to the creation of compounds necessary for rigorous biological evaluations and optimizations. This step is crucial for ensuring that the final therapeutic product retains strong cytotoxic properties to target tumor cells effectively while minimizing side effects on healthy cells.
In the expansive landscape of antitumor drug development, Dov-Val-Dil-OH illustrates the potential of marine biomes as novel sources of medicinal agents. The synthesis of dolastoxin from intermediates like Dov-Val-Dil-OH expands our toolbox of antitumor agents, providing new scaffolds for drug development. Researchers can modify the molecular structure to enhance its pharmacological properties, a process needing effective intermediates that Dov-Val-Dil-OH facilitates. This pursuit leads to the generation of highly targeted therapies that can outperform traditional chemotherapy agents in precision and minimal invasiveness.
Moreover, the study of Dov-Val-Dil-OH and its derivatives enhances our understanding of marine toxins’ mechanisms. By dissecting how these compounds operate at the molecular level, scientists can design more effective strategies to circumvent cancer resistance mechanisms. This provides invaluable insights not only into designing analogs with improved therapeutic profiles but also in understanding cell-killing mechanisms that can be fine-tuned or replicated synthetically for maximum efficacy. The strategic importance of Dov-Val-Dil-OH in synthesizing such peptides exemplifies the synergy between natural product chemistry and innovative cancer treatment paradigms.
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BOC Sciences offers comprehensive services for ADC manufacturing, including antibody modification, linker chemistry, payload conjugation, and formulation development. In particular, our payload-linker customization service offers a convenient and fast raw material channel for many ADC researchers.
BOC Sciences provides one-stop site-specific conjugation services for amino acids, glycans, unnatural amino acids, and short peptide tags. In addition, cysteine conjugation, lysine conjugation, enzymatic conjugation, thio-engineered antibody can also be obtained quickly.
BOC Sciences offers a full range of linkers, including peptide linkers, PEG linkers, click chemistry, PROTAC linkers, non-cleavable linkers, etc. We also provide custom development services for chemically labile linkers and enzymatically cleavable linkers.
