Name: Lycorine hydrochloride
Brand: BOC Sciences
Price: 299 USD
Availability: MadeToOrder

Size

Price

Stock

Quantity

1 g

$299

In stock

Synonyms

Lycorine hydrochloride;2188-68-3;Lycorine chloride;Lycorine HCl;Licorin hydrochloride;Lycorine (hydrochloride);58F70VH0HS;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol,2,4,5,7,12b,12c-hexahydro-, hydrochloride (1:1), (1S,2S,12bS,12cS)-;(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride;(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride;MFCD00243111;Lycorine-chloride;UNII-58F70VH0HS;SCHEMBL8437600;CHEMBL2092590;DTXSID80944478;VUVNTYCHKZBOMV-NVJKKXITSA-N;GLXC-03849;LYCORINE HYDROCHLORIDE [MI];(1S,2S,12BS,12CS)-2,4,5,7,12B,12C-HEXAHYDRO-1H-(1,3)DIOXOLO(4,5-J)PYRROLO(3,2,1-DE)PHENANTHRIDINE-1,2-DIOL HYDROCHLORIDE;HY-N0289;Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride;s3800;AKOS030228351;LYCORINE HYDROCHLORIDE, (+)-;CCG-267737;CS-5954;Lycorine hydrochloride;Lycorine chloride;AC-34971;BS-42350;DA-75213;Galanthan-1,2-diol, 3-12-didehydro-9,10-(methylenebis(oxy))-, hydrochloride, (1-alpha,2-beta)-;Lycorine hydrochloride, >=98% (TLC), powder;Q-100273;Q27261592;(1S,2S,3a1S,12bS)-2,3a1,4,5,7,12b-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diolhydrochloride;1H-(1,3)DIOXOLO(4,5-J)PYRROLO(3,2,1-DE)PHENANTHRIDINE-1,2-DIOL, 2,4,5,7,12B,12C-HEXAHYDRO-, HYDROCHLORIDE (1:1), (1S,2S,12BS,12CS)-;2,4,5,7,12b,12c-Hexahydro-1H,10H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol--hydrogen chloride (1/1);

IUPAC Name

(1S,17S,18S,19S)-5,7-dioxa-12-azapentacyclo[10.6.1.02,10.04,8.015,19]nonadeca-2,4(8),9,15-tetraene-17,18-diol;hydrochloride

Canonical SMILES

[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])S(=O)(=O)C1=CC=C(C=C1)C(=O)O

InChI

InChI=1S/C16H17NO4.ClH/c18-11-3-8-1-2-17-6-9-4-12-13(21-7-20-12)5-10(9)14(15(8)17)16(11)19;/h3-5,11,14-16,18-19H,1-2,6-7H2;1H/t11-,14-,15+,16+;/m0./s1

InChIKey

VUVNTYCHKZBOMV-NVJKKXITSA-N

Solubility

Slightly in 95% alcohol, not well in water, not in chloroform

Melting Point

210-212 °C.

Appearance

Solid

Shipping

Room temperature

Storage

4°C, sealed storage, away from moisture<br />*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Pictograms

Acute Toxic

Signal Word

Danger

1.Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma.

Li X;Xu P;Wang C;Xu N;Xu A;Xu Y;Sadahira T;Araki M;Wada K;Matsuura E;Watanabe M;Zheng J;Sun P;Huang P;Nasu Y;Liu C Oncotarget. 2017 Mar 28;8(13):21177-21186. doi: 10.18632/oncotarget.15505.

Renal cell carcinoma (RCC) management has undergone a major transformation over the past decade; immune checkpoint inhibitors are currently undergoing clinical trials and show promising results. However, the effectiveness of immune checkpoint inhibitors in patients with metastatic RCC (mRCC) is still limited. Lycorine, an alkaloid extracted from plants of the Amaryllidaceae family, is touted as a potential anti-cancer drug because of its demonstrative growth inhibition capacity (induction of cell cycle arrest and inhibition of vasculogenic mimicry formation). Moreover, T cell checkpoint blockade therapy with antibodies targeting cytotoxic T-lymphocyte associated protein 4 (CTLA-4) has improved outcomes in cancer patients. However, the anti-tumor efficacy of combined lycorine and anti-CTLA-4 therapy remains unknown. Thus, we investigated a combination therapy of lycorine hydrochloride and anti-CTLA-4 using a murine RCC model. As a means of in vitro confirmation, we found that lycorine hydrochloride inhibited the viability of various RCC cell lines. Furthermore, luciferase-expressing Renca cells were implanted in the left kidney and the lung of BALB/c mice to develop a RCC metastatic mouse model.

HPLC

HNMR