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CAS No.: 2055198-04-2
Cat No.: BADC-01050
Purity: >98.0%
4.5 
PC-Biotin-PEG4-PEG3-azide is a multifunctional ADC linker combining biotin affinity, PEG spacers, and azide reactivity, enabling site-specific copper-free click chemistry conjugation and streamlined purification in ADC production.
Structure of 2055198-04-2
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Popular Publications Citing BOC Sciences Products
PC-Biotin-PEG4-PEG3-azide is an advanced ADC linker intermediate designed for targeted antibody-drug conjugate (ADC) construction and precise bioconjugation applications. It combines a photoreactive (PC) group, biotin functionality, PEG4-PEG3 spacers, and a terminal azide, enabling dual conjugation strategies through photo-crosslinking and click chemistry. The PEG4-PEG3 spacers provide flexibility, reduce steric hindrance, and improve solubility of ADC payloads. In ADC linker design, PC-Biotin-PEG4-PEG3-azide supports site-specific attachment of cytotoxic payloads while preserving antibody stability and biological activity, allowing controlled intracellular delivery in tumor-targeted therapies.
In payload conjugation applications, PC-Biotin-PEG4-PEG3-azide is compatible with a broad spectrum of ADC cytotoxins, including microtubule inhibitors, DNA-targeting agents, and other potent therapeutic molecules. The photoreactive group enables covalent crosslinking upon UV activation, while the azide functionality allows bioorthogonal click chemistry for modular payload attachment. The biotin moiety provides additional utility for purification or detection. Together, the PEG4-PEG3 spacers enhance solubility, reduce aggregation, and facilitate homogeneous ADC construction, ensuring reproducible conjugation and optimized pharmacokinetics.
From an application perspective, PC-Biotin-PEG4-PEG3-azide is widely used in oncology-focused ADC research, protein bioconjugation studies, and multifunctional targeted drug delivery systems. Its combination of photoreactive chemistry, biotin labeling, and flexible PEG spacers enables precise, site-specific conjugation while maintaining antibody integrity. Leveraging this linker in ADC design allows researchers to create customizable, dual-functional linker-payload conjugates capable of efficient tumor targeting and selective intracellular payload release, tailored for complex therapeutic strategies.
| Catalog | Product Name | CAS | Inquiry |
|---|---|---|---|
| BADC-01524 | Biotin-PEG1-azide | 1204085-48-2 | |
| BADC-00903 | NHS-SS-biotin | 122266-55-1 | |
| BADC-01699 | Biotin-PEG(4)-SS-Azide | 1260247-52-6 | |
| BADC-01728 | Biotin-PEG4-SS-Alkyne | 1260247-54-8 | |
| BADC-01523 | Biotin-PEG4-PFP ester | 1334172-58-5 | |
| BADC-00935 | Biotin-PEG2-acid | 1365655-89-5 | |
| BADC-01016 | PC Biotin-PEG3-alkyne | 1869922-24-6 | |
| BADC-01022 | PC Biotin-PEG3-azide | 1937270-46-6 | |
| BADC-01672 | Biotin-PEG4-MeTz | 1962919-31-8 | |
| BADC-01810 | Biotin-PEG3-Me-Tet | 2143968-06-1 |
What is PC-Biotin-PEG4-PEG3-azide used for in ADC development?
PC-Biotin-PEG4-PEG3-azide is a multifunctional linker combining a photocleavable biotin moiety with PEG spacers and an azide functional group. It allows photo-triggered release and bioorthogonal conjugation of payloads to antibodies for controlled studies.
29/9/2017
We would like to know how PC-Biotin-PEG4-PEG3-azide facilitates controlled release in ADCs.
The photocleavable group can be activated by specific wavelengths of light, enabling spatial and temporal control over payload release. This feature is valuable for mechanistic studies and targeted therapy applications.
19/6/2022
Could you kindly advise what conjugation strategies are compatible with PC-Biotin-PEG4-PEG3-azide?
The azide functional group allows for copper-free click chemistry with DBCO-modified antibodies, while the PEG4-PEG3 spacers improve solubility and reduce steric interference during conjugation.
29/8/2016
Good morning! Can PC-Biotin-PEG4-PEG3-azide be used in therapeutic ADCs?
Its primary use is in research and preclinical studies due to the photocleavable design. While in vivo therapeutic applications are possible, considerations regarding light penetration and stability must be addressed.
19/9/2020
Good morning! What analytical methods are recommended to confirm the integrity of PC-Biotin-PEG4-PEG3-azide?
The integrity of PC-Biotin-PEG4-PEG3-azide can be assessed using LC-MS or HPLC to confirm molecular identity and detect potential degradation products. UV-Vis spectroscopy may also be used to monitor the biotin moiety during storage and handling.
12/1/2023
— Dr. Robert Evans, Protein Chemist (USA)
PC-Biotin-PEG4-PEG3-azide linker enabled efficient biotinylation with minimal side reactions.
29/8/2016
— Prof. Elena Russo, Medicinal Chemist (Italy)
High-purity PC-Biotin-PEG4-PEG3-azide delivered by BOC Sciences facilitated downstream applications.
12/1/2023
— Dr. Stefan Weber, Bioconjugation Specialist (Germany)
The PEG4-PEG3 spacer improved solubility and flexibility, enhancing conjugation efficiency.
19/9/2020
— Ms. Laura Smith, R&D Manager (UK)
Excellent documentation and timely delivery accompanied this biotinylation linker.
29/9/2017
— Dr. Ingrid Jensen, ADC Project Lead (Denmark)
Using PC-Biotin-PEG4-PEG3-azide, we achieved consistent biotin labeling across multiple experiments.
— Mr. Felix Martin, Senior Scientist (France)
The linker’s quality and solubility enhanced our high-throughput conjugation workflow.
19/6/2022
PC-Biotin-PEG4-PEG3-azide
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PC-Biotin-PEG4-PEG3-azide
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