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Biotin-PEG(4)-SS-Azide

  CAS No.: 1260247-52-6   Cat No.: BADC-01699 4.5  

Biotin-PEG(4)-SS-Azide is a biotinylated ADC linker with PEG4 spacer, cleavable disulfide bond, and azide group enabling targeted delivery, bioorthogonal conjugation, and controlled payload release in antibody-drug conjugates. Keywords: ADC linker, biotin linker, PEG spacer, disulfide cleavable, azide linker.

Biotin-PEG(4)-SS-Azide

Structure of 1260247-52-6

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ADC Linker
Molecular Formula
C29H52N8O8S3
Molecular Weight
736.97

* For research and manufacturing use only. We do not sell to patients.

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Popular Publications Citing BOC Sciences Products

Biotin-PEG(4)-SS-Azide, a versatile chemical compound often employed in bioconjugation and biolabeling applications, boasts unique structural properties. Here are four key applications of Biotin-PEG(4)-SS-Azide, presented with high perplexity and burstiness:

Bioconjugation: Harnessing the power of Biotin-PEG(4)-SS-Azide, researchers forge connections between biomolecules through the mighty biotin-streptavidin bond, renowned for its strength. This linkage enables the attachment of biotinylated molecules to diverse surfaces or other biomolecules, facilitating the exploration of biological interactions. The PEG spacer plays a critical role in reducing steric hindrance, enhancing the accessibility and functionality of the biotin group, thereby amplifying the versatility of bioconjugation experiments.

Drug Delivery Systems: Pioneering targeted drug delivery systems, Biotin-PEG(4)-SS-Azide emerges as a game-changer. By conjugating therapeutic agents to biotin via the azide group, researchers achieve precise delivery through biotin-receptor interactions, ensuring drugs reach diseased cells with pinpoint accuracy. This targeted approach minimizes off-target effects while maximizing therapeutic efficacy.

Bioimaging: Within the realm of bioimaging, Biotin-PEG(4)-SS-Azide takes center stage as a vital tool for labeling and tracking biological molecules within cellular landscapes. The biotin moiety facilitates the attachment of fluorescent or radioactive streptavidin conjugates, enabling researchers to visualize target molecules in real-time. This cutting-edge technique revolutionizes the study of cellular processes and molecular localization, offering unprecedented insights into the dynamic inner workings of living systems.

Proteomics: In the realm of proteomics, Biotin-PEG(4)-SS-Azide proves its mettle in the selective enrichment and identification of biotinylated proteins. Following the labeling of proteins with Biotin-PEG(4)-SS-Azide, researchers leverage streptavidin-coated beads to capture the marked proteins. This innovative approach streamlines the isolation and analysis of specific proteins from complex biological samples.

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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